Burden of liver diseases in the world

SK Asrani, H Devarbhavi, J Eaton, PS Kamath - Journal of hepatology, 2019 - Elsevier
Liver disease accounts for approximately 2 million deaths per year worldwide, 1 million due
to complications of cirrhosis and 1 million due to viral hepatitis and hepatocellular …

l‐ornithine l‐aspartate in acute treatment of severe hepatic encephalopathy: a double‐blind randomized controlled trial

A Jain, BC Sharma, B Mahajan, S Srivastava… - Hepatology, 2022 - journals.lww.com
Conclusions HBsAg‐positive patients with HCC are at high or intermediate risk of HBV
reactivation depending on the type of HCC therapy. Nucleos (t) ide analogue prophylaxis …

Off-therapy response after nucleos (t) ide analogue withdrawal in patients with chronic hepatitis B: an international, multicenter, multiethnic cohort (RETRACT-B study)

G Hirode, HSJ Choi, CH Chen, TH Su, WK Seto… - Gastroenterology, 2022 - Elsevier
Background & Aims Functional cure, defined based on hepatitis B surface antigen (HBsAg)
loss, is rare during nucleos (t) ide analogue (NA) therapy and guidelines on finite NA …

Fructose promotes leaky gut, endotoxemia, and liver fibrosis through ethanol‐inducible cytochrome P450‐2E1–mediated oxidative and nitrative stress

YE Cho, DK Kim, W Seo, B Gao, SH Yoo, BJ Song - Hepatology, 2021 - journals.lww.com
Fructose intake is known to induce obesity, insulin resistance, metabolic syndrome, and
nonalcoholic fatty liver disease (NAFLD). We aimed to evaluate the effects of fructose …

Limited sustained response after stopping nucleos (t) ide analogues in patients with chronic hepatitis B: results from a randomised controlled trial (Toronto STOP study …

KS Liem, S Fung, DK Wong, C Yim, S Noureldin… - Gut, 2019 - gut.bmj.com
Objective Although most patients with chronic hepatitis B (CHB) reach effective virological
suppression with long-term nucleos (t) ide analogues (NA) therapy, some might not need to …

Hepatitis B surface antigen seroclearance: immune mechanisms, clinical impact, importance for drug development

I Tout, D Loureiro, A Mansouri, V Soumelis, N Boyer… - Journal of …, 2020 - Elsevier
HBsAg seroclearance occurs rarely in the natural history of chronic hepatitis B (CHB)
infection and is associated with improved clinical outcomes. Many factors are associated …

Optimizing systemic therapy for advanced hepatocellular carcinoma: the key role of liver function

G Cabibbo, A Aghemo, Q Lai, M Masarone… - Digestive and Liver …, 2022 - Elsevier
The number of effective systemic therapies for the treatment of advanced hepatocellular
carcinoma (HCC) is rapidly increasing, and the advent of immunotherapy has changed the …

Comparison of tenofovir and entecavir on the risk of hepatocellular carcinoma and mortality in treatment-naïve patients with chronic hepatitis B in Korea: a large-scale …

SW Lee, JH Kwon, HL Lee, SH Yoo, HC Nam, PS Sung… - Gut, 2020 - gut.bmj.com
Objective The use of tenofovir (TDF) and entecavir (ETV) in patients with chronic hepatitis B
(CHB) has led to a decrease in the incidence of hepatocellular carcinoma (HCC) and liver …

[PDF][PDF] Hepatitis B treatment: what we know now and what remains to be researched

A Suk‐Fong Lok - Hepatology communications, 2019 - Wiley Online Library
Chronic hepatitis B virus (HBV) infection remains a major global health burden. Currently,
two types of treatment, interferons (IFNs) and nucleos (t) ide analogues (NAs), have been …

Similar risk of hepatocellular carcinoma during long-term entecavir or tenofovir therapy in Caucasian patients with chronic hepatitis B

GV Papatheodoridis, GN Dalekos, R Idilman… - Journal of …, 2020 - Elsevier
Background & Aims A recent study in Asian patients with chronic hepatitis B (CHB) reported
that the incidence of hepatocellular carcinoma (HCC) was lower in patients treated with …