Multi-omics approaches for biomarker discovery in early ovarian cancer diagnosis

Y Xiao, M Bi, H Guo, M Li - EBioMedicine, 2022 - thelancet.com
Ovarian cancer (OC) is a heterogeneous disease with the highest mortality rate and the
poorest prognosis among gynecological malignancies. Because of the absence of specific …

Gastric cancer: where are we heading?

P Petryszyn, N Chapelle, T Matysiak-Budnik - Digestive Diseases, 2020 - karger.com
Background: Despite its decreasing incidence, gastric cancer (GC) remains one of the
leading cancers in the world and an important global healthcare problem due to its overall …

Large‐scale plasma proteomic profiling identifies a high‐performance biomarker panel for Alzheimer's disease screening and staging

Y Jiang, X Zhou, FC Ip, P Chan, Y Chen… - Alzheimer's & …, 2022 - Wiley Online Library
Introduction Blood proteins are emerging as candidate biomarkers for Alzheimer's disease
(AD). We systematically profiled the plasma proteome to identify novel AD blood biomarkers …

Circulating proteins as diagnostic markers in gastric cancer

O Repetto, R Vettori, A Steffan, R Cannizzaro… - International Journal of …, 2023 - mdpi.com
Gastric cancer (GC) is a highly malignant disease affecting humans worldwide and has a
poor prognosis. Most GC cases are detected at advanced stages due to the cancer lacking …

The CDCP1 signaling hub: a target for cancer detection and therapeutic intervention

T Khan, T Kryza, NJ Lyons, Y He, JD Hooper - Cancer research, 2021 - AACR
CUB-domain containing protein 1 (CDCP1) is a type I transmembrane glycoprotein that is
upregulated in malignancies of the breast, lung, colorectum, ovary, kidney, liver, pancreas …

The mechanism and role of ADAMTS protein family in osteoarthritis

T Li, J Peng, Q Li, Y Shu, P Zhu, L Hao - Biomolecules, 2022 - mdpi.com
Osteoarthritis (OA) is a principal cause of aches and disability worldwide. It is characterized
by the inflammation of the bone leading to degeneration and loss of cartilage function …

Challenges and opportunities in clinical applications of blood-based proteomics in cancer

R Bhawal, AL Oberg, S Zhang, M Kohli - Cancers, 2020 - mdpi.com
Simple Summary The traditional approach in identifying cancer related protein biomarkers
has focused on evaluation of a single peptide/protein in tissue or circulation. At best, this …

Integrated meta-analysis of colorectal cancer public proteomic datasets for biomarker discovery and validation

J Robles, A Prakash, JA Vizcaíno… - PLOS Computational …, 2024 - journals.plos.org
The cancer biomarker field has been an object of thorough investigation in the last decades.
Despite this, colorectal cancer (CRC) heterogeneity makes it challenging to identify and …

PPARδ dysregulation of CCL20/CCR6 axis promotes gastric adenocarcinoma carcinogenesis by remodeling gastric tumor microenvironment

Y Liu, D Wei, Y Deguchi, W Xu, R Tian, F Liu, M Xu… - Gastric Cancer, 2023 - Springer
Background Peroxisome proliferator-activated receptor delta (PPARδ) promotes
inflammation and carcinogenesis in many organs, but the underlying mechanisms remains …

Data-driven decision-making for precision diagnosis of digestive diseases

S Jiang, T Wang, KH Zhang - BioMedical Engineering Online, 2023 - Springer
Modern omics technologies can generate massive amounts of biomedical data, providing
unprecedented opportunities for individualized precision medicine. However, traditional …