The ability to respond to genotoxic stress is a prerequisite for the successful development of
the nervous system. Mutations in various DNA repair factors can lead to human diseases …

Active maintenance of genome stability is a prerequisite for the development and function of
the nervous system. The high replication index during neurogenesis and the long life of …

Defects in DNA repair have been linked to cognitive decline with age and
neurodegenerative disease, yet the mechanisms that protect neurons from genotoxic stress …

Oxidative stress is a key contributor to AD pathology. However, the earliest role of pre-
plaque neuronal oxidative stress, remains elusive. Using laser microdissected hippocampal …

Aberrant cell-cycle activity and DNA damage are emerging as important pathological
components in various neurodegenerative conditions. However, their underlying …

Reactivation of the cell cycle, including DNA replication, might play a major role in
Alzheimer's disease (AD). A more than diploid DNA content in differentiated neurons might …

Neuronal DNA repair remains one of the most exciting areas for investigation, particularly as
a means to compare the DNA repair response in mitotic (cancer) vs. post-mitotic (neuronal) …

Background Previous studies have demonstrated reexpression of cell-cycle markers within
postmitotic neurons in neurodegenerative tauopathies, including Alzheimer's disease (AD) …

The integrity of the human genome is frequently challenged by endogenous and exogenous
agents, and reactive oxygen species (ROS) constitute the major endogenous source of DNA …

Alzheimer's disease (AD) is a chronic neurodegenerative disorder, characterized by
synaptic degeneration associated with fibrillar aggregates of the amyloid-ß peptide and the …