The average dietary salt (ie, sodium chloride) intake in Western society is about 10 g per
day. This greatly exceeds the lifestyle recommendations by the WHO to limit dietary salt …

Many physiological processes, including most kidney-related functions, follow specific
rhythms tied to a 24-h cycle. This is largely because circadian genes operate in virtually …

The Western diet is characterized by high protein, sugar, fat, and low fiber intake, and is
widely believed to contribute to the incidence and pathogenesis of inflammatory bowel …

Background Disturbances in renal microcirculation play an important role in the
pathophysiology of chronic kidney disease (CKD), but the lack of easy accessible …

The G protein–coupled estrogen receptor 1 (GPER1) mediates rapid estrogenic signaling.
We recently reported that activation of GPER1 in the renal medulla evokes endothelin-1 …

The influence of excess salt intake on acute kidney injury (AKI) has not been examined
precisely except for some clinical data, unlike in chronic kidney disease. Here, we …

Proper renal blood flow (RBF) and glomerular filtration rate (GFR) are critical for maintaining
normal blood pressure, kidney function and water and electrolyte homeostasis. The renal …

Abstract Endothelin 1 (ET-1) seems essential in salt-dependent hypertension, and activation
of ETA receptors causes renal vasoconstriction. However, the response in the renal medulla …

Aim We aimed to test the hypothesis that a high‐salt diet (HS) impairs NO signaling in
kidney microvascular endothelial cells through a histone deacetylase 1 (HDAC1) …

Abstract Aims Endothelin (ET)-1 promotes natriuresis via the endothelin B receptor (ET B)
within the renal medulla. In male rats, direct interstitial infusion of ET-1 into the renal medulla …