Specialized subpopulations of CD4+ T cells survey major histocompatibility complex class II–
peptide complexes to control phagosomal infections, help B cells, regulate tissue …

The lungs are constantly exposed to inhaled debris, allergens, pollutants, commensal or
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …

Single-cell transcriptomics has allowed unprecedented resolution of cell types/states in the
human lung, but their spatial context is less well defined. To (re) define tissue architecture of …

Lymphocytes are key for immune surveillance of tumors, but our understanding of the spatial
organization and physical interactions that facilitate lymphocyte anti-cancer functions is …

Programmed cell death protein-1 (PD-1) is a checkpoint receptor expressed on the surface
of various immune cells. PD-L1, the natural receptor for PD-1, is mainly expressed in tumor …

Aberrant immune responses to resident microbes promote inflammatory bowel disease and
other chronic inflammatory conditions. However, how microbiota-specific immunity is …

The lungs are constantly exposed to environmental and infectious agents such as dust,
viruses, fungi, and bacteria that invade the lungs upon breathing. The lungs are equipped …

Pneumonia is inflammation in the lungs, which is usually caused by an infection. The
symptoms of pneumonia can vary from mild to life-threatening, where severe illness is often …

Durable reconstitution of the distal lung epithelium with pluripotent stem cell (PSC)
derivatives, if realized, would represent a promising therapy for diseases that result from …

Mucosal immunity plays a significant role in the first-line defense against viruses transmitted
and infected through the respiratory system, such as SARS-CoV-2. However, the lack of …