Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non-
malignant diseases. This is consistent with numerous findings about differentiation …

In mammals, DNA methylation is introduced by the DNMT1, DNMT3A and DNMT3B
methyltransferases, which are all large multi-domain proteins containing a catalytic C …

Neuroinflammation is a fundamental contributor to progressive neuronal damage, which
arouses a heightened interest in neurodegenerative disease therapy. Ubiquitin-specific …

The ubiquitin system regulates essential cellular processes in eukaryotes. Ubiquitin is
ligated to substrate proteins as monomers or chains and the topology of ubiquitin …

As part of the epigenetic network, DNA methylation is a major regulator of chromatin
structure and function. In mammals, it mainly occurs at palindromic CpG sites, but …

Stable inheritance of DNA methylation is critical for maintaining differentiated phenotypes in
multicellular organisms. We have recently identified dual mono-ubiquitylation of histone H3 …

Genetic alterations, including DNA mutations and chromosomal abnormalities, are primary
drivers of tumor formation and cancer progression. These alterations can endow cells with a …

Chromatin functions are influenced by the addition, removal, and recognition of histone post-
translational modifications (PTMs). Ubiquitin and ubiquitin-like (UBL) PTMs on histone …

Turnover of cellular proteins is regulated by Ubiquitin Proteasome System (UPS).
Components of this pathway, including the proteasome, ubiquitinating enzymes and …

Ubiquitin specific protease 7 (USP7) is one of the deubiquitinating enzymes (DUB) that
erases ubiquitin and protects substrate protein from degradation. Full activity of USP7 …