Mass spectrometry approaches to glycomic and glycoproteomic analyses
Glycomic and glycoproteomic analyses involve the characterization of oligosaccharides
(glycans) conjugated to proteins. Glycans are produced through a complicated nontemplate …
(glycans) conjugated to proteins. Glycans are produced through a complicated nontemplate …
Protein analysis by shotgun/bottom-up proteomics
According to Genome Sequencing Project statistics (http://www. ncbi. nlm. nih.
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …
gov/genomes/static/gpstat. html), as of February 16, 2012, complete gene sequences have …
Vertebrate protein glycosylation: diversity, synthesis and function
KW Moremen, M Tiemeyer, AV Nairn - Nature reviews Molecular cell …, 2012 - nature.com
Protein glycosylation is a ubiquitous post-translational modification found in all domains of
life. Despite their significant complexity in animal systems, glycan structures have crucial …
life. Despite their significant complexity in animal systems, glycan structures have crucial …
Glycans and glycoproteins as specific biomarkers for cancer
Protein glycosylation and other post-translational modifications are involved in potentially all
aspects of human growth and development. Defective glycosylation has adverse effects on …
aspects of human growth and development. Defective glycosylation has adverse effects on …
Oligosaccharide analysis by mass spectrometry: a review of recent developments
Carbohydrates are central players in a number of important biological processes including
cell signaling, cell adhesion, and the regulation of biochemical pathways. Unlike nucleic …
cell signaling, cell adhesion, and the regulation of biochemical pathways. Unlike nucleic …
Characterization of isomeric glycan structures by LC‐MS/MS
The characterization of glycosylation is critical for obtaining a comprehensive view of the
regulation and functions of glycoproteins of interest. Due to the complex nature of …
regulation and functions of glycoproteins of interest. Due to the complex nature of …
Annotation and structural elucidation of bovine milk oligosaccharides and determination of novel fucosylated structures
DL Aldredge, MR Geronimo, S Hua, CC Nwosu… - …, 2013 - academic.oup.com
Bovine milk oligosaccharides (BMOs) are recognized by the dairy and food industries, as
well as by infant formula manufacturers, as novel, high-potential bioactive food ingredients …
well as by infant formula manufacturers, as novel, high-potential bioactive food ingredients …
Comprehensive structural glycomic characterization of the glycocalyxes of cells and tissues
The glycocalyx comprises glycosylated proteins and lipids and fcorms the outermost layer of
cells. It is involved in fundamental inter-and intracellular processes, including non-self-cell …
cells. It is involved in fundamental inter-and intracellular processes, including non-self-cell …
Direct comparison of derivatization strategies for LC-MS/MS analysis of N-glycans
Protein glycosylation is a common post-translational modification that has significant impacts
on protein folding, lifespan, conformation, distribution and function. N-Glycans, which are …
on protein folding, lifespan, conformation, distribution and function. N-Glycans, which are …
Glycosylation of biosimilars: Recent advances in analytical characterization and clinical implications
Over the past few years, loss of patent protection for blockbuster monoclonal antibody (mAb)
drugs has caused a significant shift in the pharmaceutical industry towards the development …
drugs has caused a significant shift in the pharmaceutical industry towards the development …