Acetylcholine in the brain alters neuronal excitability, influences synaptic transmission,
induces synaptic plasticity, and coordinates firing of groups of neurons. As a result, it …

Developmental periods such as gestation and adolescence have enhanced plasticity
leaving the brain vulnerable to harmful effects from nicotine use. Proper brain maturation …

Subtypes of neuronal nicotinic acetylcholine receptors (nAChRs) are constructed from
numerous subunit combinations that compose channel-receptor complexes with varied …

Nicotine reinforces smoking behavior by activating nicotinic acetylcholine receptors
(nAChRs) in the midbrain dopaminergic (DA) reward centers, including the ventral …

The past two decades have witnessed a dramatic accumulation of evidence indicating that
the excitatory amino acid glutamate plays an important role in drug addiction and …

Alzheimer's disease is a complex disorder affecting multiple neurotransmitters. In particular,
the degenerative progression is associated with loss within the cholinergic systems. It …

This study reveals mechanisms in the mouse hippocampus that may underlie nicotinic
influences on attention, memory, and cognition. Induction of synaptic plasticity, arising via …

Acetylcholine (ACh) is an important neurotransmitter in the mammalian brain; it is implicated
in arousal, learning, and other cognitive functions. Recent studies indicate that nicotinic …

During brain ontogenesis, the temporal and spatial generation of the different types of
neuronal and glial cells from precursors occurs as a sequence of successive progenitor …

Nicotinic ACh receptors (nAChRs) have been implicated in a variety of brain functions,
including neuronal development, learning and memory formation, and reward. Although …