Free radicals and oxidants are involved in physiological signaling pathways, although an
imbalance between pro-oxidant and anti-oxidant systems in favor of the former leads to …

Neurotrophins, such as brain-derived neurotrophic factor (BDNF), are prominent regulators
of neuronal survival, growth and differentiation during development. While trophic factors are …

In this perspective, we summarize and discuss critical advancements in the study of 4-
hydroxy-2-nonenal (4-HNE) as it relates to diseases and clinical complications either …

Under physiological conditions, cells are in a stable state known as redox homeostasis,
which is maintained by the balance between continuous ROS/RNS generation and several …

Abstract Systems medicine is founded on a mechanism-based approach and identifies in
this way specific therapeutic targets. This approach has been applied for the transcription …

Type 2 diabetes mellitus (T2DM) is a risk factor for Alzheimer disease (AD). Previous studies
have shown that the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose …

Modern analytical methods combined with the modern concepts of redox signaling revealed
4-hydroxy-2-nonenal (4-HNE) as particular growth regulating factor involved in redox …

Parkinson's disease (PD) is the second most common neurodegenerative disease, and
there is no recognised therapy to cure it. Recently, it has been shown that treatments to …

Background: Parkinson's disease (PD) is a progressive neurodegenerative disease for
which there is no cure. In a clinical trial, the glucagon-like peptide-1 (GLP-1) receptor …

In contrast to the general belief that regeneration is a rare event, mainly occurring in simple
organisms, the ability of regeneration is widely distributed in the animal kingdom. Yet, the …