Almost 60 years have passed since the initial discovery by Hubel and Wiesel that changes
in neuronal activity can elicit developmental rewiring of the central nervous system (CNS) …

Sensory areas are spontaneously active in the absence of sensory stimuli. This
spontaneous activity has long been studied; however, its functional role remains largely …

Microglia regulate synaptic circuit remodeling and phagocytose synaptic material in the
healthy brain; however, the mechanisms directing microglia to engulf specific synapses and …

Maturation of neuronal circuits requires selective elimination of synaptic connections.
Although neuron-intrinsic mechanisms are important in this process, it is increasingly …

INTRODUCTION Fundamental circuit features of the mouse visual system emerge before
the onset of vision, allowing the mouse to perceive objects and detect visual motion …

Reductions in blood flow to the brain of sufficient duration and extent lead to stroke, which
results in damage to neuronal networks and the impairment of sensation, movement or …

Spike timing–dependent plasticity (STDP) as a Hebbian synaptic learning rule has been
demonstrated in various neural circuits over a wide spectrum of species, from insects to …

How learning and memory is achieved in the brain is a central question in neuroscience.
Key to today's research into information storage in the brain is the concept of synaptic …

Vision is the sense humans rely on most to navigate the world, make decisions, and perform
complex tasks. Understanding how humans see thus represents one of the most …

Before the onset of sensory transduction, developing neural circuits spontaneously generate
correlated activity in distinct spatial and temporal patterns. During this period of patterned …