Malaria medicines: a glass half full?
TNC Wells, RH Van Huijsduijnen… - Nature Reviews Drug …, 2015 - nature.com
Despite substantial scientific progress over the past two decades, malaria remains a
worldwide burden that causes hundreds of thousands of deaths every year. New, affordable …
worldwide burden that causes hundreds of thousands of deaths every year. New, affordable …
Picornavirus and enterovirus diversity with associated human diseases
C Tapparel, F Siegrist, TJ Petty, L Kaiser - Infection, Genetics and Evolution, 2013 - Elsevier
Members of the Picornaviridae family are non-enveloped, positive-stranded RNA viruses
with a 30nm icosahedral capsid. This virus family exhibits a considerable amount of genetic …
with a 30nm icosahedral capsid. This virus family exhibits a considerable amount of genetic …
LoFreq: a sequence-quality aware, ultra-sensitive variant caller for uncovering cell-population heterogeneity from high-throughput sequencing datasets
The study of cell-population heterogeneity in a range of biological systems, from viruses to
bacterial isolates to tumor samples, has been transformed by recent advances in …
bacterial isolates to tumor samples, has been transformed by recent advances in …
Rhinoviruses and Respiratory Enteroviruses: Not as Simple as ABC
L Royston, C Tapparel - Viruses, 2016 - mdpi.com
Rhinoviruses (RVs) and respiratory enteroviruses (EVs) are leading causes of upper
respiratory tract infections and among the most frequent infectious agents in humans …
respiratory tract infections and among the most frequent infectious agents in humans …
Challenges and opportunities in estimating viral genetic diversity from next-generation sequencing data
Many viruses, including the clinically relevant RNA viruses HIV (human immunodeficiency
virus) and HCV (hepatitis C virus), exist in large populations and display high genetic …
virus) and HCV (hepatitis C virus), exist in large populations and display high genetic …
[HTML][HTML] Astrovirus MLB2, a new gastroenteric virus associated with meningitis and disseminated infection
Next-generation sequencing has identified novel astroviruses for which a pathogenic role is
not clearly defined. We identified astrovirus MLB2 infection in an immunocompetent case …
not clearly defined. We identified astrovirus MLB2 infection in an immunocompetent case …
Plagues upon the Earth: disease and the course of human history
K Harper - 2021 - torrossa.com
Introduction microorganisms and macrohistory one of the chief blessings of living in the
modern world is supposed to be that the risk of dying from an infectious disease has become …
modern world is supposed to be that the risk of dying from an infectious disease has become …
Deep sequencing of influenza A virus from a human challenge study reveals a selective bottleneck and only limited intrahost genetic diversification
Knowledge of influenza virus evolution at the point of transmission and at the intrahost level
remains limited, particularly for human hosts. Here, we analyze a unique viral data set of …
remains limited, particularly for human hosts. Here, we analyze a unique viral data set of …
Beyond the consensus: dissecting within-host viral population diversity of foot-and-mouth disease virus by using next-generation genome sequencing
The diverse sequences of viral populations within individual hosts are the starting material
for selection and subsequent evolution of RNA viruses such as foot-and-mouth disease virus …
for selection and subsequent evolution of RNA viruses such as foot-and-mouth disease virus …
Effects of rhinovirus species on viral replication and cytokine production
K Nakagome, YA Bochkov, S Ashraf… - Journal of Allergy and …, 2014 - Elsevier
Background Epidemiologic studies provide evidence of differential virulence of rhinovirus
species (RV). We recently reported that RV-A and RV-C induced more severe illnesses than …
species (RV). We recently reported that RV-A and RV-C induced more severe illnesses than …