Salivarian trypanosomes are the causative agents of several diseases of major social and
economic impact. The most infamous parasites of this group are the African subspecies of …

The execution of the apoptotic death program in metazoans is characterized by a sequence
of morphological and biochemical changes that include cell shrinkage, presentation of …

Unicellular organisms, such as the protozoan parasite Leishmania, can be stimulated to
show some morphological and biochemical features characteristic of mammalian apoptosis …

Programmed cell death (apoptosis) is an important regulator of the host's response during
infection with a variety of intracellular protozoan parasites. Parasitic pathogens have …

Abstract Tsetse flies (Diptera: Glossinidae) are vectors of several species of pathogenic
trypanosomes in tropical Africa. Human African trypanosomiasis (HAT) is a zoonosis caused …

Apoptosis is a normal component of the development and health of multicellular organisms.
However, apoptosis is now considered a prerogative of unicellular organisms, including the …

RNA interference (RNAi) is a powerful tool for identifying gene function in Trypanosoma
brucei. We generated an RNAi library, the first of its kind in any organism, by ligation of …

Trypanosoma brucei possesses five metacaspase genes. Of these, MCA2 and MCA3 are
expressed only in the mammalian bloodstream form of the parasite, whereas MCA5 is …

Abstract Background The protozoan pathogen, Trypanosoma brucei, undergoes complex
cycles of differentiation and multiplication in its vector, the tsetse fly, genus Glossina. Flies …

The survival of Trypanosoma brucei, the causative agent of Sleeping Sickness and Nagana,
is facilitated by the expression of a dense surface coat of glycosylphosphatidylinositol (GPI) …