The E factor at 30: a passion for pollution prevention

RA Sheldon - Green Chemistry, 2023 - pubs.rsc.org
The introduction of the E Factor in 1992 focussed attention on the problem of waste
generation, defined as everything but the desired product, in chemicals manufacture and …

Where chemocatalysis meets biocatalysis: In water

H Gröger, F Gallou, BH Lipshutz - Chemical Reviews, 2022 - ACS Publications
Chemoenzymatic catalysis, by definition, involves the merging of sequential reactions using
both chemocatalysis and biocatalysis, typically in a single reaction vessel. A major …

Water as the reaction medium in organic chemistry: from our worst enemy to our best friend

M Cortes-Clerget, J Yu, JRA Kincaid, P Walde… - Chemical …, 2021 - pubs.rsc.org
Water as the reaction medium in organic chemistry: from our worst enemy to our best friend -
Chemical Science (RSC Publishing) DOI:10.1039/D0SC06000C Royal Society of Chemistry …

Shortening synthetic routes to small molecule active pharmaceutical ingredients employing biocatalytic methods

S Simić, E Zukić, L Schmermund, K Faber… - Chemical …, 2021 - ACS Publications
Biocatalysis, using enzymes for organic synthesis, has emerged as powerful tool for the
synthesis of active pharmaceutical ingredients (APIs). The first industrial biocatalytic …

Expanding the synthetic toolbox through metal–enzyme cascade reactions

S González-Granda, J Albarrán-Velo… - Chemical …, 2023 - ACS Publications
The combination of metal-, photo-, enzyme-, and/or organocatalysis provides multiple
synthetic solutions, especially when the creation of chiral centers is involved. Historically …

The Hitchhiker's guide to biocatalysis: recent advances in the use of enzymes in organic synthesis

RA Sheldon, D Brady, ML Bode - Chemical science, 2020 - pubs.rsc.org
Enzymes are excellent catalysts that are increasingly being used in industry and academia.
This perspective is primarily aimed at synthetic organic chemists with limited experience …

Introducing Savie: A biodegradable surfactant enabling chemo-and biocatalysis and related reactions in recyclable water

JRA Kincaid, MJ Wong, N Akporji… - Journal of the …, 2023 - ACS Publications
Savie is a biodegradable surfactant derived from vitamin E and polysarcosine (PSar)
developed for use in organic synthesis in recyclable water. This includes homogeneous …

One-pot chemo-and photo-enzymatic linear cascade processes

JM Carceller, KS Arias, MJ Climent, S Iborra… - Chemical Society …, 2024 - pubs.rsc.org
The combination of chemo-and photocatalyses with biocatalysis, which couples the flexible
reactivity of the photo-and chemocatalysts with the highly selective and environmentally …

Status check: biocatalysis; it's use with and without chemocatalysis. How does the fine chemicals industry view this area?

F Gallou, H Gröger, BH Lipshutz - Green Chemistry, 2023 - pubs.rsc.org
Biocatalytic processes used alone, as well as part of chemoenzymatic catalysis, would
appear to be very attractive areas to several types of companies that make up the fine …

Biocatalysis in drug discovery and development

A Fryszkowska, PN Devine - Current Opinion in Chemical Biology, 2020 - Elsevier
Enzyme catalysis, enabled by advances in protein engineering and directed evolution, is
beginning to transform chemical synthesis in the pharmaceutical industry. This review …