The abscission checkpoint contributes to the fidelity of chromosome segregation by delaying
completion of cytokinesis (abscission) when there is chromatin lagging in the intercellular …

Genomic instability is a hallmark of cancer and a common feature of human disorders,
characterized by growth defects, neurodegeneration, cancer predisposition, and aging …

Despite its evolutionarily conserved function in controlling DNA replication, the
chromosomal binding sites of the budding yeast Rif1 protein are not well understood. Here …

Telomeres are a significant challenge to DNA replication and are prone to replication stress
and telomere fragility. The shelterin component TRF1 facilitates telomere replication but the …

The anaphase of mitosis is one of the most critical stages of the cell division cycle in that it
can reveal precious information on the fate of a cell lineage. Indeed, most types of nuclear …

DNA replication is spatially and temporally regulated during S phase to execute efficient and
coordinated duplication of entire genome. Various epigenomic mechanisms operate to …

In the presence of chromatin bridges, mammalian cells delay completion of cytokinesis
(abscission) to prevent chromatin breakage or tetraploidization by regression of the …

Resolution of ultrafine anaphase bridges (UFBs) must be completed before cytokinesis to
ensure sister-chromatid disjunction. RIF1 is involved in UFB resolution by a mechanism that …

Chromosome replication and transcription occur within a complex nuclear milieu whose
functional subdomains are beginning to be mapped out. Here we delineate distinct domains …

In fission yeast lacking the telomere binding protein, Taz1, replication forks stall at
telomeres, triggering deleterious downstream events. Strand invasion from one taz1Δ …