Amyloidoses are an array of diseases associated with the aggregation of proteins into fibrils.
While it was previously thought that amyloid fibril-forming proteins are exclusively host-cell …

The order of Bunyavirales includes numerous (re) emerging viruses that collectively have a
major impact on human and animal health worldwide. There are no vaccines for human use …

Amyloid fibrils result from the aggregation of host cell-encoded proteins, many giving rise to
specific human illnesses such as Alzheimer's disease. Here we show that the major …

Various stressors such as viral infection lead to the suppression of cap-dependent
translation and the activation of the integrated stress response (ISR), since the stress …

Viral infection triggers activation of the integrated stress response (ISR). In response to viral
double-stranded RNA (dsRNA), RNA-activated protein kinase (PKR) phosphorylates the …

Alphaviruses, such as chikungunya virus (CHIKV), are mosquito-borne viruses that
represent a significant threat to human health due to the current context of global warming …

Guertu virus (GTV) is a potentially highly pathogenic bunyavirus newly isolated in China,
which is genetically related to the severe fever with thrombocytopenia syndrome virus …

Rift Valley fever (RVF) is a zoonotic viral disease that affects domestic and wild ruminants
such as cattle, sheep, goats, camels, and buffaloes. Rift Valley fever phlebovirus (RVFV), the …

The integrated stress response (ISR) protects cells from a variety of insults. Once elicited
(eg, by virus infections), it eventually leads to the block of mRNA translation. Central to the …

Rift Valley fever virus (RVFV) is a high‐priority zoonotic pathogen with the ability to cause
massive loss during its outbreak within a very short period of time. Lack of a highly sensitive …