Cancer-associated fibroblasts: overview, progress, challenges, and directions
Q Ping, R Yan, X Cheng, W Wang, Y Zhong… - Cancer gene …, 2021 - nature.com
Tumors are one of the main causes of death in humans. The development of safe and
effective methods for early diagnosis and treatment of tumors is a difficult problem that needs …
effective methods for early diagnosis and treatment of tumors is a difficult problem that needs …
IL-6/STAT3 is a promising therapeutic target for hepatocellular carcinoma
J Xu, H Lin, G Wu, M Zhu, M Li - Frontiers in oncology, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC) is a common malignant tumor of which the occurrence and
development, the tumorigenicity of HCC is involving in multistep and multifactor interactions …
development, the tumorigenicity of HCC is involving in multistep and multifactor interactions …
TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer
L Caja, F Dituri, S Mancarella… - International journal of …, 2018 - mdpi.com
Transforming growth factor-β (TGF-β) is a cytokine essential for the induction of the fibrotic
response and for the activation of the cancer stroma. Strong evidence suggests that a strong …
response and for the activation of the cancer stroma. Strong evidence suggests that a strong …
Mechanisms underlying hepatitis C virus-associated hepatic fibrosis
Hepatitis C virus (HCV) infection often causes liver diseases, including fibrosis, cirrhosis and
hepatocellular carcinoma (HCC). Liver fibrosis is the outcome of the wound healing …
hepatocellular carcinoma (HCC). Liver fibrosis is the outcome of the wound healing …
Molecular changes in relation to alcohol consumption and hepatocellular carcinoma
Alcohol is the one of the major causes of liver diseases and promotes liver cirrhosis and
hepatocellular carcinoma (HCC). In hepatocytes, alcohol is converted to acetaldehyde …
hepatocellular carcinoma (HCC). In hepatocytes, alcohol is converted to acetaldehyde …
[HTML][HTML] Changes of gut-microbiota-liver axis in hepatitis C virus infection
M El-Mowafy, A Elgaml, M El-Mesery, S Sultan… - Biology, 2021 - mdpi.com
The gut–liver-axis is a bidirectional coordination between the gut, including microbial
residents, the gut microbiota, from one side and the liver on the other side. Any disturbance …
residents, the gut microbiota, from one side and the liver on the other side. Any disturbance …
JP3, an antiangiogenic peptide, inhibits growth and metastasis of gastric cancer through TRIM25/SP1/MMP2 axis
JJ Chen, YL Ren, CJ Shu, Y Zhang, MJ Chen… - Journal of Experimental …, 2020 - Springer
Background Gastric cancer (GC) is the most prevalent gastrointestinal tumor with an
unfavorable clinical prognosis. GC patients are largely threatened owing to metastasis and …
unfavorable clinical prognosis. GC patients are largely threatened owing to metastasis and …
A novel 12-marker panel of cancer-associated fibroblasts involved in progression of hepatocellular carcinoma
B Zou, X Liu, Y Gong, C Cai, P Li, S Xing… - Cancer Management …, 2018 - Taylor & Francis
Background/Aim Cancer-associated fibroblasts (CAFs) are important factors in the
progression of hepatocellular carcinoma (HCC). But the characterization of these cells …
progression of hepatocellular carcinoma (HCC). But the characterization of these cells …
Chronic liver diseases: From development to novel pharmacological therapies: IUPHAR Review 37
MT Borrello, D Mann - British Journal of Pharmacology, 2023 - Wiley Online Library
Chronic liver diseases comprise a broad spectrum of burdensome diseases that still lack
effective pharmacological therapies. Our research group focuses on fibrosis, which is a …
effective pharmacological therapies. Our research group focuses on fibrosis, which is a …
Molecular crosstalk between the hepatitis C virus and the extracellular matrix in liver fibrogenesis and early carcinogenesis
E Reungoat, B Grigorov, F Zoulim, EI Pécheur - Cancers, 2021 - mdpi.com
Simple Summary In the era of direct-acting antivirals against the hepatitis C virus (HCV),
curing chronic hepatitis C has become a reality. However, while replicating chronically, HCV …
curing chronic hepatitis C has become a reality. However, while replicating chronically, HCV …