Cancer-associated fibroblasts: overview, progress, challenges, and directions

Q Ping, R Yan, X Cheng, W Wang, Y Zhong… - Cancer gene …, 2021 - nature.com
Tumors are one of the main causes of death in humans. The development of safe and
effective methods for early diagnosis and treatment of tumors is a difficult problem that needs …

IL-6/STAT3 is a promising therapeutic target for hepatocellular carcinoma

J Xu, H Lin, G Wu, M Zhu, M Li - Frontiers in oncology, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC) is a common malignant tumor of which the occurrence and
development, the tumorigenicity of HCC is involving in multistep and multifactor interactions …

TGF-β and the Tissue Microenvironment: Relevance in Fibrosis and Cancer

L Caja, F Dituri, S Mancarella… - International journal of …, 2018 - mdpi.com
Transforming growth factor-β (TGF-β) is a cytokine essential for the induction of the fibrotic
response and for the activation of the cancer stroma. Strong evidence suggests that a strong …

Mechanisms underlying hepatitis C virus-associated hepatic fibrosis

M Khatun, RB Ray - Cells, 2019 - mdpi.com
Hepatitis C virus (HCV) infection often causes liver diseases, including fibrosis, cirrhosis and
hepatocellular carcinoma (HCC). Liver fibrosis is the outcome of the wound healing …

Molecular changes in relation to alcohol consumption and hepatocellular carcinoma

R Sasaki-Tanaka, R Ray, M Moriyama, RB Ray… - International Journal of …, 2022 - mdpi.com
Alcohol is the one of the major causes of liver diseases and promotes liver cirrhosis and
hepatocellular carcinoma (HCC). In hepatocytes, alcohol is converted to acetaldehyde …

[HTML][HTML] Changes of gut-microbiota-liver axis in hepatitis C virus infection

M El-Mowafy, A Elgaml, M El-Mesery, S Sultan… - Biology, 2021 - mdpi.com
The gut–liver-axis is a bidirectional coordination between the gut, including microbial
residents, the gut microbiota, from one side and the liver on the other side. Any disturbance …

JP3, an antiangiogenic peptide, inhibits growth and metastasis of gastric cancer through TRIM25/SP1/MMP2 axis

JJ Chen, YL Ren, CJ Shu, Y Zhang, MJ Chen… - Journal of Experimental …, 2020 - Springer
Background Gastric cancer (GC) is the most prevalent gastrointestinal tumor with an
unfavorable clinical prognosis. GC patients are largely threatened owing to metastasis and …

A novel 12-marker panel of cancer-associated fibroblasts involved in progression of hepatocellular carcinoma

B Zou, X Liu, Y Gong, C Cai, P Li, S Xing… - Cancer Management …, 2018 - Taylor & Francis
Background/Aim Cancer-associated fibroblasts (CAFs) are important factors in the
progression of hepatocellular carcinoma (HCC). But the characterization of these cells …

Chronic liver diseases: From development to novel pharmacological therapies: IUPHAR Review 37

MT Borrello, D Mann - British Journal of Pharmacology, 2023 - Wiley Online Library
Chronic liver diseases comprise a broad spectrum of burdensome diseases that still lack
effective pharmacological therapies. Our research group focuses on fibrosis, which is a …

Molecular crosstalk between the hepatitis C virus and the extracellular matrix in liver fibrogenesis and early carcinogenesis

E Reungoat, B Grigorov, F Zoulim, EI Pécheur - Cancers, 2021 - mdpi.com
Simple Summary In the era of direct-acting antivirals against the hepatitis C virus (HCV),
curing chronic hepatitis C has become a reality. However, while replicating chronically, HCV …