Addressing uncertainty in genome-scale metabolic model reconstruction and analysis
The reconstruction and analysis of genome-scale metabolic models constitutes a powerful
systems biology approach, with applications ranging from basic understanding of genotype …
systems biology approach, with applications ranging from basic understanding of genotype …
[HTML][HTML] A navigation guide of synthetic biology tools for Pseudomonas putida
Pseudomonas putida is a microbial chassis of huge potential for industrial and
environmental biotechnology, owing to its remarkable metabolic versatility and ability to …
environmental biotechnology, owing to its remarkable metabolic versatility and ability to …
Forest and trees: exploring bacterial virulence with genome-wide association studies and machine learning
The advent of inexpensive and rapid sequencing technologies has allowed bacterial whole-
genome sequences to be generated at an unprecedented pace. This wealth of information …
genome sequences to be generated at an unprecedented pace. This wealth of information …
Emerging evasion mechanisms of macrophage defenses by pathogenic bacteria
C Leseigneur, P Lê-Bury, J Pizarro-Cerdá… - Frontiers in Cellular …, 2020 - frontiersin.org
Macrophages participate to the first line of defense against infectious agents. Microbial
pathogens evolved sophisticated mechanisms to escape macrophage killing. Here, we …
pathogens evolved sophisticated mechanisms to escape macrophage killing. Here, we …
Metabolic Versatility of Mycobacterium tuberculosis during Infection and Dormancy
DPS Chang, XL Guan - Metabolites, 2021 - mdpi.com
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is a highly
successful intracellular pathogen with the ability to withstand harsh conditions and reside …
successful intracellular pathogen with the ability to withstand harsh conditions and reside …
Recent advances in constraint and machine learning-based metabolic modeling by leveraging stoichiometric balances, thermodynamic feasibility and kinetic law …
Understanding the governing principles behind organisms' metabolism and growth
underpins their effective deployment as bioproduction chassis. A central objective of …
underpins their effective deployment as bioproduction chassis. A central objective of …
From genotype to phenotype: computational approaches for inferring microbial traits relevant to the food industry
When selecting microbial strains for the production of fermented foods, various microbial
phenotypes need to be taken into account to achieve target product characteristics, such as …
phenotypes need to be taken into account to achieve target product characteristics, such as …
Mycobacterium tuberculosis Metabolism
Mycobacterium tuberculosis is the cause of tuberculosis (TB), a disease which continues to
overwhelm health systems in endemic regions despite the existence of effective combination …
overwhelm health systems in endemic regions despite the existence of effective combination …
Genetic Diversity in Mycobacterium tuberculosis Clinical Isolates and Resulting Outcomes of Tuberculosis Infection and Disease
Tuberculosis claims more human lives than any other bacterial infectious disease and
represents a clear and present danger to global health as new tools for vaccination …
represents a clear and present danger to global health as new tools for vaccination …
Expanding the search for small-molecule antibacterials by multidimensional profiling
K Ortmayr, R de la Cruz Moreno, M Zampieri - Nature Chemical Biology, 2022 - nature.com
New techniques for systematic profiling of small-molecule effects can enhance traditional
growth inhibition screens for antibiotic discovery and change how we search for new …
growth inhibition screens for antibiotic discovery and change how we search for new …