Epicardial adipose tissue in contemporary cardiology

G Iacobellis - Nature reviews cardiology, 2022 - nature.com
Interest in epicardial adipose tissue (EAT) is growing rapidly, and research in this area
appeals to a broad, multidisciplinary audience. EAT is unique in its anatomy and …

Efficacy and safety of semaglutide on weight loss in obese or overweight patients without diabetes: A systematic review and meta-analysis of randomized controlled …

X Gao, X Hua, X Wang, W Xu, Y Zhang… - Frontiers in …, 2022 - frontiersin.org
Objectives: This study aims to explore the weight loss effect and safety of semaglutide as a
conventional anti-obesity drug systematically in obese or overweight patients without …

Epicardial adipose tissue and outcome in heart failure with mid-range and preserved ejection fraction

G van Woerden, DJ van Veldhuisen… - Circulation: Heart …, 2022 - Am Heart Assoc
Background: Epicardial adipose tissue (EAT) accumulation is thought to play a role in the
pathophysiology of heart failure (HF) with mid-range and preserved ejection fraction, but its …

Management of Obesity in Cardiovascular Practice: JACC Focus Seminar

JP Despres, AC Carpentier, A Tchernof… - Journal of the American …, 2021 - jacc.org
Obesity contributes to reduced life expectancy because of its link with type 2 diabetes and
cardiovascular disease. Yet, targeting this poorly diagnosed, ill-defined, and …

Semaglutide modulates prothrombotic and atherosclerotic mechanisms, associated with epicardial fat, neutrophils and endothelial cells network

D García-Vega, D Sánchez-López… - Cardiovascular …, 2024 - Springer
Background Obesity has increased in recent years with consequences on diabetes and
other comorbidities. Thus, 1 out of 3 diabetic patients suffers cardiovascular disease (CVD) …

Dysregulated epicardial adipose tissue as a risk factor and potential therapeutic target of heart failure with preserved ejection fraction in diabetes

T Salvatore, R Galiero, A Caturano, E Vetrano… - Biomolecules, 2022 - mdpi.com
Cardiovascular (CV) disease and heart failure (HF) are the leading cause of mortality in type
2 diabetes (T2DM), a metabolic disease which represents a fast-growing health challenge …

Once-weekly semaglutide in people with HIV-associated lipohypertrophy: a randomised, double-blind, placebo-controlled phase 2b single-centre clinical trial

AR Eckard, Q Wu, A Sattar, K Ansari-Gilani… - The Lancet Diabetes & …, 2024 - thelancet.com
Background HIV-associated lipohypertrophy, which is characterised by an abnormal
accumulation of abdominal visceral adipose tissue, remains problematic in people with HIV …

Human epicardial adipose tissue expresses glucose-dependent insulinotropic polypeptide, glucagon, and glucagon-like peptide-1 receptors as potential targets of …

AE Malavazos, G Iacobellis, E Dozio… - European journal of …, 2023 - academic.oup.com
Aims Human epicardial adipose tissue (EAT) plays a crucial role in the development and
progression of coronary artery disease, atrial fibrillation, and heart failure. Microscopically …

Efficacy and safety of semaglutide 2.4 mg for weight loss in overweight or obese adults without diabetes: An updated systematic review and meta‐analysis including …

W Qin, J Yang, C Deng, Q Ruan… - Diabetes, Obesity and …, 2024 - Wiley Online Library
Aim To explore the safety and efficacy of subcutaneous semaglutide 2.4 mg, administered
once a week in non‐diabetic overweight or obese individuals. Methods A thorough search …

Glucagon-like peptide-1 receptor agonists across the spectrum of heart failure

JP Ferreira, A Sharma, J Butler, M Packer… - The Journal of …, 2024 - academic.oup.com
Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have been used to reduce body
weight in overweight or people with obesity and to improve glycemic control and …