Immunomodulation—a general review of the current state-of-the-art and new therapeutic strategies for targeting the immune system
M Strzelec, J Detka, P Mieszczak… - Frontiers in …, 2023 - frontiersin.org
In recent years, there has been a tremendous development of biotechnological,
pharmacological, and medical techniques which can be implemented in the functional …
pharmacological, and medical techniques which can be implemented in the functional …
Non-steroidal anti-inflammatory drugs: Recent advances in the use of synthetic COX-2 inhibitors
M Ahmadi, S Bekeschus, KD Weltmann… - RSC Medicinal …, 2022 - pubs.rsc.org
Cyclooxygenase (COX) enzymes comprise COX-1 and COX-2 isoforms and are responsible
for prostaglandin production. Prostaglandins have critical roles in the inflammation pathway …
for prostaglandin production. Prostaglandins have critical roles in the inflammation pathway …
Design, synthesis and mechanistic study of new 1, 2, 4-triazole derivatives as antimicrobial agents
NH Amin, MT El-Saadi, AA Ibrahim… - Bioorganic …, 2021 - Elsevier
Abstract Novel 5-amino-1, 2, 4-triazole derivatives and their cyclized 1, 2, 4-triazolo [1, 5-a]
pyrimidine analogues were designed, synthesized and evaluated for their antimicrobial …
pyrimidine analogues were designed, synthesized and evaluated for their antimicrobial …
Small molecule soluble epoxide hydrolase inhibitors in multitarget and combination therapies for inflammation and cancer
A Das Mahapatra, R Choubey, B Datta - Molecules, 2020 - mdpi.com
The enzyme soluble epoxide hydrolase (sEH) plays a central role in metabolism of bioactive
lipid signaling molecules. The substrate-specific hydrolase activity of sEH converts …
lipid signaling molecules. The substrate-specific hydrolase activity of sEH converts …
Recent advances in biological active sulfonamide based hybrid compounds Part A: Two-component sulfonamide hybrids
Sulfonamides constitute an important class of drugs, with many types of pharmacological
agents possessing antibacterial, anti-carbonic anhydrase, anti-obesity, diuretic …
agents possessing antibacterial, anti-carbonic anhydrase, anti-obesity, diuretic …
Small molecule compounds with good anti-inflammatory activity reported in the literature from 01/2009 to 05/2021: A review
M Bian, Q Ma, Y Wu, H Du… - Journal of enzyme …, 2021 - Taylor & Francis
Inflammation and disease are closely related. Inflammation can induce various diseases,
and diseases can promote inflammatory response, and two possibly induces each other in a …
and diseases can promote inflammatory response, and two possibly induces each other in a …
Potential effect of novel thiadiazole derivatives against radiation induced inflammation with low cardiovascular risk in rats
NH Zaher, MM El-Sheikh, RM El-Hazek… - Medicinal Chemistry …, 2022 - Springer
The aim of the present study is to explore new selective anti-inflammatory compounds with
low cardiovascular risk. Twelve thiadiazole derivatives incorporating different amino acid …
low cardiovascular risk. Twelve thiadiazole derivatives incorporating different amino acid …
Towards safer anti-inflammatory therapy: synthesis of new thymol–pyrazole hybrids as dual COX-2/5-LOX inhibitors
MMM El-Miligy, AK Al-Kubeisi, MG Bekhit… - Journal of Enzyme …, 2023 - Taylor & Francis
Abstract New thymol− 1, 5-disubstitutedpyrazole hybrids were synthesised as dual COX-2/5-
LOX inhibitors. Compounds 8b, 8g, 8c, and 4a displayed in vitro inhibitory activity against …
LOX inhibitors. Compounds 8b, 8g, 8c, and 4a displayed in vitro inhibitory activity against …
Further exploration of the structure-activity relationship of dual soluble epoxide hydrolase/fatty acid amide hydrolase inhibitors
S Wilt, S Kodani, L Valencia, PK Hudson… - Bioorganic & medicinal …, 2021 - Elsevier
Fatty acid amide hydrolase (FAAH) is a membrane protein that hydrolyzes
endocannabinoids, and its inhibition produces analgesic and anti-inflammatory effects. The …
endocannabinoids, and its inhibition produces analgesic and anti-inflammatory effects. The …
New pyrimidine/thiazole hybrids endowed with analgesic, anti‐inflammatory, and lower cardiotoxic activities: Design, synthesis, and COX‐2/sEH dual inhibition
SA Abdel‐Aziz, ES Taher, P Lan… - Archiv der …, 2022 - Wiley Online Library
Abstract Some cyclooxygenase (COX)‐2 selective medications were withdrawn from the
market just a few years after their production due to cardiovascular side effects. In this study …
market just a few years after their production due to cardiovascular side effects. In this study …