In recent years, there has been a tremendous development of biotechnological,
pharmacological, and medical techniques which can be implemented in the functional …

Cyclooxygenase (COX) enzymes comprise COX-1 and COX-2 isoforms and are responsible
for prostaglandin production. Prostaglandins have critical roles in the inflammation pathway …

Abstract Novel 5-amino-1, 2, 4-triazole derivatives and their cyclized 1, 2, 4-triazolo [1, 5-a]
pyrimidine analogues were designed, synthesized and evaluated for their antimicrobial …

The enzyme soluble epoxide hydrolase (sEH) plays a central role in metabolism of bioactive
lipid signaling molecules. The substrate-specific hydrolase activity of sEH converts …

Sulfonamides constitute an important class of drugs, with many types of pharmacological
agents possessing antibacterial, anti-carbonic anhydrase, anti-obesity, diuretic …

Inflammation and disease are closely related. Inflammation can induce various diseases,
and diseases can promote inflammatory response, and two possibly induces each other in a …

The aim of the present study is to explore new selective anti-inflammatory compounds with
low cardiovascular risk. Twelve thiadiazole derivatives incorporating different amino acid …

Abstract New thymol− 1, 5-disubstitutedpyrazole hybrids were synthesised as dual COX-2/5-
LOX inhibitors. Compounds 8b, 8g, 8c, and 4a displayed in vitro inhibitory activity against …

Fatty acid amide hydrolase (FAAH) is a membrane protein that hydrolyzes
endocannabinoids, and its inhibition produces analgesic and anti-inflammatory effects. The …

Abstract Some cyclooxygenase (COX)‐2 selective medications were withdrawn from the
market just a few years after their production due to cardiovascular side effects. In this study …