The lipid droplet in cancer: From being a tumor‐supporting hallmark to clinical therapy
Y Cui, S Man, J Tao, Y Liu, L Ma, L Guo… - Acta …, 2024 - Wiley Online Library
Introduction Abnormal lipid metabolism, one of the hallmarks in cancer, has gradually
emerged as a novel target for cancer treatment. As organelles that store and release excess …
emerged as a novel target for cancer treatment. As organelles that store and release excess …
Statins—from fungi to pharmacy
A Sadowska, P Osiński, A Roztocka… - International Journal of …, 2023 - mdpi.com
Statins have been used in the treatment of hyperlipidemia, both as monotherapy and in
combination therapy. Natural fermentation processes of fungi such as Monascus spp …
combination therapy. Natural fermentation processes of fungi such as Monascus spp …
Motor function and physiology in youth with neurofibromatosis type 1
Abstract Background Neurofibromatosis type 1 (NF1) is a genetic neurocutaneous disorder
commonly associated with motor and cognitive symptoms that greatly impact quality of life …
commonly associated with motor and cognitive symptoms that greatly impact quality of life …
Neurophysiological effects of a combined treatment of lovastatin and minocycline in patients with fragile X syndrome: Ancillary results of the LOVAMIX randomized …
F Morin‐Parent, C Champigny, S Côté… - Autism …, 2024 - Wiley Online Library
Fragile X syndrome (FXS) is the primary hereditary cause of intellectual disability and autism
spectrum disorder. It is characterized by exacerbated neuronal excitability, and its correction …
spectrum disorder. It is characterized by exacerbated neuronal excitability, and its correction …
Impact of acquisition and modeling parameters on the test–retest reproducibility of edited GABA+
Literature values vary widely for within‐subject test–retest reproducibility of gamma‐
aminobutyric acid (GABA) measured with edited magnetic resonance spectroscopy (MRS) …
aminobutyric acid (GABA) measured with edited magnetic resonance spectroscopy (MRS) …
Hyperactivation of MEK1 in cortical glutamatergic neurons results in projection axon deficits and aberrant motor learning
GR Bjorklund, KP Rees… - Disease Models & …, 2024 - journals.biologists.com
Abnormal Extracellular Regulated Kinase 1/2 (ERK1/2) signaling is linked to multiple
neurodevelopmental diseases, especially the RASopathies, which typically exhibit ERK1/2 …
neurodevelopmental diseases, especially the RASopathies, which typically exhibit ERK1/2 …
Statins in Children with Neurofibromatosis Type 1: A Systematic Review of Randomized Controlled Trials
AP Agouridis, N Palli, VE Karagiorga, A Konsoula… - Children, 2023 - mdpi.com
Background: Statins, apart from their plasma-cholesterol-lowering ability, exert several
pleiotropic effects, making them a potential treatment for other diseases. Animal studies …
pleiotropic effects, making them a potential treatment for other diseases. Animal studies …
Aculeatones A and B, epimeric lovastatin derivatives with a 6/6/3-tricyclic carbon skeleton from Aspergillus aculeatus and their chemical transformation
F Liu, F Wang, Q Li, B Dai, W Sun, J Li… - Organic Chemistry …, 2024 - pubs.rsc.org
Lovastatin and its derivatives are well-known as a class of lipid-lowering drugs in the
medicinal chemistry of natural products, and they typically feature a rigid decalin core …
medicinal chemistry of natural products, and they typically feature a rigid decalin core …
Social Communication in Ras Pathway Disorders: A Comprehensive Review from Genetics to Behavior in Neurofibromatosis Type 1 and Noonan Syndrome
M Siqueiros-Sanchez, Y Serur, CA McGhee… - Biological …, 2024 - Elsevier
Abstract Neurofibromatosis type 1 (NF1) and Noonan syndrome (NS) are neurogenetic
syndromes caused by pathogenetic variants encoding components of the Ras-ERK-MAPK …
syndromes caused by pathogenetic variants encoding components of the Ras-ERK-MAPK …