Part I of this article discussed the potential functional importance of genetic mutations and
alleles of the human cytochrome P450 2D6 (CYP2D6) gene. The impact of CYP2D6 …

Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …

Abstract Cytochrome P450 2C19 (CYP2C19) is the main (or partial) cause for large
differences in the pharmacokinetics of a number of clinically important drugs. On the basis of …

The five selective serotonin reuptake inhibitors (SSRIs), fluoxetine, fluvoxamine, paroxetine,
sertraline, and citalopram, have similar antidepressant efficacy and a similar side effect …

We investigated the elimination routes for the 200 drugs that are sold most often by
prescription count in the United States. The majority (78%) of the hepatically cleared drugs …

The selective serotonin reuptake inhibitors (SSRIs) have emerged as a major therapeutic
advance in psychopharmacology. As a result, the discovery of these agents marks a …

Background: Single isomers of the selective serotonin reuptake inhibitors citalopram
(escitalopram, S-citalopram) and fluoxetine (R-fluoxetine) are currently under development …

The selective serotonin reuptake inhibitors (SSRIs) have become the most prescribed
antidepressants in many countries. Although the SSRIs share a common mechanism of …

This article reviews the metabolic pharmacokinetic drug-drug interactions with the systemic
antifungal agents: the azoles ketoconazole, miconazole, itraconazole and fluconazole, the …

Detailed knowledge of metabolism of drugs is crucial for two main reasons. First, metabolism
determines to a large extent pharmacokinetic behaviour, interindividual variability and …