The impact of thyroid hormone dysfunction on ischemic heart disease

M von Hafe, JS Neves, C Vale… - Endocrine …, 2019 - ec.bioscientifica.com
Thyroid hormones have a central role in cardiovascular homeostasis. In myocardium, these
hormones stimulate both diastolic myocardial relaxation and systolic myocardial contraction …

MicroRNAs regulate mitochondrial apoptotic pathway in myocardial ischemia-reperfusion-injury

P Makhdoumi, A Roohbakhsh, G Karimi - Biomedicine & Pharmacotherapy, 2016 - Elsevier
MicroRNAs (miRNAs) are small non-coding RNAs that act as post-transcriptional gene
regulators. They are involved in the pathogenesis of different disorders including heart …

Mitochondria are transported along microtubules in membrane nanotubes to rescue distressed cardiomyocytes from apoptosis

J Shen, JH Zhang, H Xiao, JM Wu, KM He, ZZ Lv… - Cell death & …, 2018 - nature.com
Membrane nanotubes (MNTs) act as “highways” between cells to facilitate the transfer of
multiple signals and play an important role in many diseases. Our previous work reported on …

Mitochondria associated microRNA expression profiling of heart failure

X Wang, C Song, X Zhou, X Han, J Li… - BioMed research …, 2017 - Wiley Online Library
Heart failure (HF) is associated with mitochondrial dysfunction and energy metabolism
impairment. MicroRNAs are implicated in the development of heart failure. However, the …

Mitochondria-targeted drug delivery in cardiovascular disease: a long road to nano-cardio medicine

F Forini, P Canale, G Nicolini, G Iervasi - Pharmaceutics, 2020 - mdpi.com
Cardiovascular disease (CVD) represents a major threat for human health. The available
preventive and treatment interventions are insufficient to revert the underlying pathological …

Pharmacological effects and mechanisms of muscone

J Wang, H Xing, X Qin, Q Ren, J Yang, L Li - Journal of Ethnopharmacology, 2020 - Elsevier
Musk, the dried secretion from the preputial follicles of the male musk deer (genus
Moschus), possesses various pharmacological activities and has been used extensively in …

Cardioprotection by post-conditioning with exogenous triiodothyronine in isolated perfused rat hearts and isolated adult rat cardiomyocytes

HR Lieder, F Braczko, N Gedik, M Stroetges… - Basic research in …, 2021 - Springer
Ischemic post-conditioning (iPoCo) by coronary re-occlusion/reperfusion during immediate
reperfusion after prolonged myocardial ischemia reduces infarct size. Mechanical …

The role of hormones in sepsis: an integrated overview with a focus on mitochondrial and immune cell dysfunction

MJ Melis, M Miller, VBM Peters, M Singer - Clinical Science, 2023 - portlandpress.com
Sepsis is a dysregulated host response to infection that results in life-threatening organ
dysfunction. Virtually every body system can be affected by this syndrome to greater or …

Selenoprotein DIO2 is a regulator of mitochondrial function, morphology and UPRmt in human cardiomyocytes

N Bomer, MG Pavez-Giani, FE Deiman… - International journal of …, 2021 - mdpi.com
Members of the fetal-gene-program may act as regulatory components to impede
deleterious events occurring with cardiac remodeling, and constitute potential novel …

Ursolic acid modulates MMPs, collagen-I, α-SMA, and TGF-β expression in isoproterenol-induced myocardial infarction in rats

T Radhiga, S Senthil, A Sundaresan… - Human & …, 2019 - journals.sagepub.com
In the present study, the modulatory effect of ursolic acid (UA) on cardiac fibrosis and
mitochondrial and lysosomal enzymes activity in isoproterenol-induced myocardial infarction …