The adrenal cortex is divided into concentric zones. In humans the major cortical zones are
the zona glomerulosa, zona fasciculata, and zona reticularis. The adrenal cortex is a …

IGFBP-6 is an O-linked glycoprotein that preferentially binds IGF-II over IGF-I. It is a relatively
selective inhibitor of IGF-II actions including proliferation, survival and differentiation of a …

FOX families play important roles in biological processes, including metabolism,
development, differentiation, proliferation, apoptosis, migration, invasion and longevity. Here …

Transforming growth factor beta (TGF‐β) plays a key role in tumor progression, notably as a
potent inducer of epithelial–mesenchymal transition (EMT). However, all of the molecular …

Hedgehog (HH) signaling is involved in many physiological processes, and pathway
deregulation can result in a wide range of malignancies. Glioma‐associated oncogene 1 …

Transcription factor GATA4 is expressed in somatic cells of the mammalian testis. Gene
targeting studies in mice have shown that GATA4 is essential for proper differentiation and …

In recent decades it has become clear that the previous conception that neoplasia in ferrets
are rare is false. 1 A large range of case reports have been published on a wide variety of …

Ferrets have become more popular as household pets and as animal models in biomedical
research in the past 2 decades. The average life span of ferrets is about 5-11 years with …

Purpose Only a few studies have reported the role of FOXS1, a transcriptional factor, in the
tumor development process. In this article, we investigate the function of FOXS1 in distinct …

Testicular adrenal rest tumors (TART) are a frequent and fertility impairing long-term
complication in males with classic congenital adrenal hyperplasia. Due to lack of clear …