The medial prefrontal cortex (mPFC) has been proposed to link sensory inputs and
behavioral outputs to mediate the execution of learned behaviors. However, how such a link …

To understand how the brain produces behavior, we must elucidate the relationships
between neuronal connectivity and function. The medial prefrontal cortex (mPFC) is critical …

Alzheimer's disease is classified as a progressive disorder resulting from protein misfolding,
also known as proteinopathies. Proteinopathies include synucleinopathies triggered by …

Long-range axonal projections provide the foundation for functional connectivity between
brain regions and are critical in the modulation of behavior. Descending projections from …

The medial prefrontal cortex (mPFC) resolves approach-avoidance conflicts and mediates
associative processes required for learning to avoid threats. Dopamine (DA) projections …

The capacity to learn cues that predict aversive outcomes, and understand how to avoid
those outcomes, is critical for adaptive behavior. Naturalistic avoidance often means …

Active avoidance is a fundamental defensive behavior, defined as performing a voluntary
action to escape a noxious stimulus. Active avoidance serves as an adaptive response to …

The medial prefrontal cortex (mPFC) has been proposed to link sensory inputs and
behavioral outputs to mediate the execution of learned behaviors. However, how such a link …

Threat avoidance is a key survival behavior that keeps animals away from harm. However,
threat avoidance must be balanced with other behaviors important for survival and well …

To survive in challenging environments, animals need to learn to perform adaptive
behaviors when exposed to sensory information that predicts threats or rewards. The medial …