Embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSC) provide a powerful
model system to uncover fundamental mechanisms that control cellular identity during …

Chromatin is the assembly of genomic DNA and proteins packaged in the nucleus of
eukaryotic cells, which together are crucial in regulating a plethora of cellular processes …

How steroid hormone receptors (SHRs) regulate transcriptional activity remains partly
understood. Upon activation, SHRs bind the genome together with a co-regulator repertoire …

Induced pluripotent stem cells (iPSCs) can in principle differentiate into any cell of the body,
and have revolutionized biomedical research and regenerative medicine. Unlike their …

Pluripotency is a crucial feature of pluripotent stem cells, which are regulated by the core
pluripotency network consisting of key transcription factors and signaling molecules …

A phenotypic hallmark of cancer is aberrant transcriptional regulation. Transcriptional
regulation is controlled by a complicated array of molecular factors, including the presence …

Rcor2, the corepressor 2 of REST, a transcriptional repressor, is predominantly expressed in
embryonic stem cells (ESCs) and plays a major role in regulating ESC pluripotency and …

Transcription factors (TFs) are the master regulators of cellular identity, capable of driving
cell fate transitions including differentiations, reprogramming, and transdifferentiations …

Pluripotent embryonic stem cells have a unique and characteristic epigenetic profile, which
is critical for differentiation to all embryonic germ lineages. When stem cells exit the …

Las células madre embrionarias (CME) se obtienen del macizo celular interno de
blastocistos de mamíferos, y en condiciones adecuadas de cultivo tienen la capacidad de …