Maturation is the last phase of heart development that prepares the organ for strong,
efficient, and persistent pumping throughout the mammal's lifespan. This process is …

During postnatal cardiac development, cardiomyocytes mature and turn into adult ones.
Hence, all cellular properties, including morphology, structure, physiology and metabolism …

In cardiomyocytes, invaginations of the sarcolemmal membrane called t-tubules are critically
important for triggering contraction by excitation-contraction (EC) coupling. These structures …

Membrane contact sites between endoplasmic reticulum (ER) and plasma membrane (PM),
or ER-PM junctions, are found in all eukaryotic cells. In excitable cells they play unique roles …

In mammalian cardiac myocytes, the plasma membrane includes the surface sarcolemma
but also a network of membrane invaginations called transverse (t-) tubules. These …

Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are considered
immature in the sarcomere organization, contractile machinery, calcium transient, and …

Relevant, predictive normal, or disease model systems are of vital importance for drug
development. The difference between nonhuman models and humans could contribute to …

The architectural specializations and targeted delivery pathways of cardiomyocytes ensure
that L-type Ca2+ channels (CaV1. 2) are concentrated on the t-tubule sarcolemma within …

Background: Beta-2 adrenergic receptors (β2ARs) but not beta-2 adrenergic receptors
(β1ARs) form a functional complex with L-type Ca2+ channels (LTCCs) on the …

Acute Lung Injury (ALI) is characterized by widespread inflammation which in its severe
form, Acute Respiratory Distress Syndrome (ARDS), leads to compromise in respiration …