Recent advances in anti-virulence therapeutic strategies with a focus on dismantling bacterial membrane microdomains, toxin neutralization, quorum-sensing …

O Fleitas Martínez, MH Cardoso, SM Ribeiro… - Frontiers in cellular …, 2019 - frontiersin.org
Antimicrobial resistance constitutes one of the major challenges facing humanity in the
Twenty-First century. The spread of resistant pathogens has been such that the possibility of …

Mini review: bacterial membrane composition and its modulation in response to stress

JR Willdigg, JD Helmann - Frontiers in Molecular Biosciences, 2021 - frontiersin.org
Antibiotics and other agents that perturb the synthesis or integrity of the bacterial cell
envelope trigger compensatory stress responses. Focusing on Bacillus subtilis as a model …

Membrane microdomain disassembly inhibits MRSA antibiotic resistance

E García-Fernández, G Koch, RM Wagner, A Fekete… - Cell, 2017 - cell.com
A number of bacterial cell processes are confined functional membrane microdomains
(FMMs), structurally and functionally similar to lipid rafts of eukaryotic cells. How bacteria …

Exploring the existence of lipid rafts in bacteria

M Bramkamp, D Lopez - Microbiology and Molecular Biology …, 2015 - Am Soc Microbiol
An interesting concept in the organization of cellular membranes is the proposed existence
of lipid rafts. Membranes of eukaryotic cells organize signal transduction proteins into …

Farnesol and Tyrosol: Secondary Metabolites with a Crucial quorum-sensing Role in Candida Biofilm Development

CF Rodrigues, L Černáková - Genes, 2020 - mdpi.com
When living in biological and interactive communities, microorganisms use quorum-sensing
mechanisms for their communication. According to cell density, bacteria and fungi can …

Exploring functional membrane microdomains in bacteria: an overview

D Lopez, G Koch - Current opinion in microbiology, 2017 - Elsevier
Highlights•Functional membrane microdomains promote efficient oligomerization of protein
partners.•They form by colocalization of specific lipids and scaffold proteins termed …

Proteomic profiling spotlights the molecular targets and the impact of the natural antivirulent umbelliferone on stress response, virulence factors, and the quorum …

T Kasthuri, S Barath, M Nandhakumar… - Frontiers in Cellular …, 2022 - frontiersin.org
Pseudomonas aeruginosa easily adapts to newer environments and acquires several
genome flexibilities to overcome the effect of antibiotics during therapeutics, especially in …

Structural constraints and dynamics of bacterial cell wall architecture

MA de Pedro, F Cava - Frontiers in Microbiology, 2015 - frontiersin.org
The peptidoglycan wall (PG) is a unique structure which confers physical strength and
defined shape to bacteria. It consists of a net-like macromolecule of peptide interlinked …

Production of Squalene in Bacillus subtilis by Squalene Synthase Screening and Metabolic Engineering

Y Song, Z Guan, R van Merkerk… - Journal of agricultural …, 2020 - ACS Publications
Squalene synthase (SQS) catalyzes the conversion of two farnesyl pyrophosphates to
squalene, an important intermediate in between isoprene and valuable triterpenoids. In this …

Role of terpenes in plant defense to biotic stress

SL Toffolatti, G Maddalena, A Passera, P Casati… - Biocontrol agents and …, 2021 - Elsevier
Terpenes constitute a highly diverse class of chemical compounds produced by the plant
and playing a role in many functions, both physiological and ecological. Plants constantly …