[HTML][HTML] Natriuretic Peptide Signaling in Uterine Biology and Preeclampsia

Q Wu - International Journal of Molecular Sciences, 2023 - mdpi.com
Endometrial decidualization is a uterine process essential for spiral artery remodeling,
embryo implantation, and trophoblast invasion. Defects in endometrial decidualization and …

Sex-specific genetic architecture of blood pressure

ML Yang, C Xu, T Gupte, TJ Hoffmann, C Iribarren… - Nature Medicine, 2024 - nature.com
The genetic and genomic basis of sex differences in blood pressure (BP) traits remain
unstudied at scale. Here, we conducted sex-stratified and combined-sex genome-wide …

Screening embryos for polygenic disease risk: a review of epidemiological, clinical, and ethical considerations

A Capalbo, G de Wert, H Mertes… - Human reproduction …, 2024 - academic.oup.com
BACKGROUND The genetic composition of embryos generated by in vitro fertilization (IVF)
can be examined with preimplantation genetic testing (PGT). Until recently, PGT was limited …

Genetic associations of circulating cardiovascular proteins with gestational hypertension and preeclampsia

A Schuermans, B Truong, M Ardissino… - JAMA …, 2024 - jamanetwork.com
Importance Hypertensive disorders of pregnancy (HDPs), including gestational hypertension
and preeclampsia, are important contributors to maternal morbidity and mortality worldwide …

Preeclampsia prediction using machine learning and polygenic risk scores from clinical and genetic risk factors in early and late pregnancies

VP Kovacheva, BW Eberhard, RY Cohen, M Maher… - …, 2024 - Am Heart Assoc
BACKGROUND: Preeclampsia, a pregnancy-specific condition associated with new-onset
hypertension after 20-weeks gestation, is a leading cause of maternal and neonatal …

Proteome-and Transcriptome-Wide Genetic Analysis Identifies Biological Pathways and Candidate Drug Targets for Preeclampsia

M Ardissino, B Truong, EAW Slob… - Circulation: Genomic …, 2024 - ahajournals.org
BACKGROUND: Preeclampsia is a leading cause of maternal and perinatal morbidity and
mortality. However, the current understanding of its underlying biological pathways remains …

Hypertensive disorders of pregnancy and cardiovascular disease risk: a Mendelian randomisation study

L Tschiderer, YT van der Schouw, S Burgess… - Heart, 2024 - heart.bmj.com
Objective Observational studies show that hypertensive disorders of pregnancy (HDPs) are
related to unfavourable maternal cardiovascular disease (CVD) risk profiles later in life. We …

Using the methylome to predict pre-eclampsia

TJ Kaitu'u-Lino, LA Bartho, S Tong - Nature Medicine, 2023 - nature.com
Using the methylome to predict pre-eclampsia | Nature Medicine Skip to main content Thank
you for visiting nature.com. You are using a browser version with limited support for CSS. To …

[HTML][HTML] Parental genetically predicted liability for coronary heart disease and risk of adverse pregnancy outcomes: a cohort study

Á Hernáez, KH Skåra, CM Page, VR Mitter… - BMC medicine, 2024 - Springer
Background Adverse pregnancy outcomes (APO) may unmask or exacerbate a woman's
underlying risk for coronary heart disease (CHD). We estimated associations of maternal …

Differences in Cardiometabolic Proteins in Pregnancy Prioritize Relevant Targets of Preeclampsia

KJ Lindley, A Perry, M Jacobs, L Petty… - … , and vascular biology, 2024 - Am Heart Assoc
BACKGROUND: Preeclampsia is a hypertensive disorder of pregnancy characterized by
widespread vascular inflammation. It occurs frequently in pregnancy, often without known …