State of shock: contemporary Vasopressor and Inotrope use in cardiogenic shock

JE Bloom, W Chan, DM Kaye, D Stub - Journal of the American …, 2023 - Am Heart Assoc
Cardiogenic shock is characterized by tissue hypoxia caused by circulatory failure arising
from inadequate cardiac output. In addition to treating the pathologic process causing …

Inotrope and vasopressor use in cardiogenic shock: what, when and why?

K Hu, R Mathew - Current Opinion in Critical Care, 2022 - journals.lww.com
Review of the current literature fails to show significant mortality benefit with any specific
vasopressor or inotropic in CS patients. The upcoming DOREMI 2 and levosimendan versus …

Lactate clearance as a surrogate for mortality in cardiogenic shock: insights from the DOREMI trial

JA Marbach, P Di Santo, NK Kapur… - Journal of the …, 2022 - Am Heart Assoc
Background Recent studies have shown improved outcomes in cardiogenic shock through
protocols directed toward early identification and initiation of mechanical circulatory support …

Inotropes, vasopressors, and mechanical circulatory support for treatment of cardiogenic shock complicating myocardial infarction: a systematic review and network …

SM Fernando, R Mathew, B Sadeghirad… - Canadian Journal of …, 2022 - Springer
Purpose To compare the relative efficacy of supportive therapies (inotropes, vasopressors,
and mechanical circulatory support [MCS]) for adult patients with cardiogenic shock …

Inotrope versus placebo therapy in cardiogenic shock: rationale and study design of the CAPITAL DOREMI2 trial

S Parlow, P Di Santo, LH Sterling, L Goodliffe… - American heart …, 2023 - Elsevier
Background Cardiogenic shock (CS) is a state of end-organ hypoperfusion related to
cardiac dysfunction. Current guidelines recommend consideration of inotrope therapy in …

Prognostic Factors Associated with Mortality in Cardiogenic Shock—A Systematic Review and Meta-Analysis

RG Jung, C Stotts, A Gupta, G Prosperi-Porta… - NEJM …, 2024 - evidence.nejm.org
Background Cardiogenic shock remains highly associated with early mortality, with mortality
often exceeding 50%. We sought to determine the association between prognostic factors …

Transcatheter edge-to-edge repair in patients with mitral regurgitation and cardiogenic shock: a new therapeutic target

RG Jung, T Simard, P Di Santo… - Current Opinion in …, 2022 - journals.lww.com
TEER remains a promising therapeutic option in cardiogenic shock complicated by
significant mitral regurgitation, but additional research is required to identify patient and …

Improved mortality and haemodynamics with milrinone in cardiogenic shock due to acute decompensated heart failure

E Rodenas‐Alesina, F Luis Scolari, VN Wang… - ESC heart …, 2023 - Wiley Online Library
Aims Studies in cardiogenic shock (CS) often have a heterogeneous population of patients,
including those with acute myocardial infarction and acute decompensated heart failure …

Efficacy of milrinone and dobutamine in cardiogenic shock: an updated systematic review and meta-analysis

O Abdel-Razek, P Di Santo, RG Jung… - Critical Care …, 2023 - journals.lww.com
OBJECTIVES: Inotropic support is commonly used in patients with cardiogenic shock (CS).
High-quality data guiding the use of dobutamine or milrinone among this patient population …

Resource utilization and costs associated with cardiogenic shock complicating myocardial infarction: a population-Based cohort study

S Parlow, SM Fernando, M Pugliese, D Qureshi… - JACC: Advances, 2024 - jacc.org
Background Cardiogenic shock due to acute myocardial infarction (AMI-CS) is associated
with significant short-and long-term morbidity and mortality. Despite this, little is known about …