Since the seminal discovery of dendritic cells (DCs) by Steinman and Cohn in 1973, there
has been an ongoing debate to what extent macrophages and DCs are related and perform …

Glycosphingolipids (GSLs) are a specialized class of membrane lipids composed of a
ceramide backbone and a carbohydrate-rich head group. GSLs populate lipid rafts of the …

Exacerbated and persistent innate immune response marked by pro-inflammatory cytokine
expression is thought to be a major driver of chronic COVID-19 pathology. Although …

Monocytes are antigen-presenting cells (APCs) that play diverse roles in promoting or
regulating inflammatory responses, but their role in T cell stimulation is not well defined. In …

Background HIV associated neurocognitive disorders cause significant morbidity and
mortality despite the advent of highly active antiretroviral therapy. A deeper understanding of …

Priming of CD8+ T cells by dendritic cells (DCs) is crucial for the generation of effective
antitumor immune responses. Here, we describe a liposomal vaccine carrier that delivers …

Low levels of type I interferon (IFN-I) are thought to be a driving force for immune activation
and T-cell exhaustion in HIV-1 infected individuals on combination antiretroviral therapy …

Chronic neuroinflammation is observed in HIV+ individuals on suppressive combination
antiretroviral therapy (cART) and is thought to cause HIV-associated neurocognitive …

Monosialodihexosylganglioside (GM3)-presenting lipid-coated polymer nanoparticles (NPs)
that recapitulate the sequestration of human immunodeficiency virus-1 (HIV-1) particles in …

Myeloid dendritic cells (DCs) can capture HIV-1 via the receptor CD169/Siglec-1 that binds
to the ganglioside, GM3, in the virus particle membrane. In turn, HIV-1 particles captured by …