Platelets are necessary for maintaining haemostasis. Separately, platelets are important for
the propagation of inflammation during the host immune response against infection. The …

Platelets are small anucleate blood cells supporting vascular function. They circulate in a
quiescent state monitoring the vasculature for injuries. Platelets adhere to injury sites and …

BACKGROUND: Heparin-induced thrombocytopenia (HIT) is a major concern for all
individuals that undergo cardiac bypass surgeries or require prolonged heparin exposure …

Background Most platelet agonists work through G protein-coupled receptors, activating
pathways that involve members of the G q, G i, and G 12/G 13 families of heterotrimeric G …

Antiplatelet agents, particularly P2Y12 receptor inhibitors, are critical medicines in the
prevention and treatment of thrombotic diseases in the clinic. However, their long-term use …

Background Many platelet agonists mediate their cellular effects through G protein-coupled
receptors (GPCRs) to induce platelet activation, and GPCR kinases (GRKs) have been …

Background The hemostatic plug formation at sites of vascular injury is strongly dependent
on rapid platelet activation and integrin-mediated adhesion and aggregation. However, to …

Der humane (h) P2Y 12-Rezeptor ist ein Gi-Protein-gekoppelter-Rezeptor, der zu einer der
bedeutendsten Proteingruppen des menschlichen Organismus gehört und über die …

OBJECTIVE: This study intends to explore the effects of Rosuvastatin on ox-LDL induced
platelet activation and its molecular mechanism. METHODS: Platelet aggregation rate was …

Thrombotic diseases have high disability rates, high mortality rates, and seriously endanger
human health and safety. Platelets play an important role in the process of thrombus …