Artificial biocatalytic linear cascades for preparation of organic molecules
JH Schrittwieser, S Velikogne, M Hall… - Chemical …, 2018 - ACS Publications
The review compiles artificial cascades involving enzymes with a focus on the last 10 years.
A cascade is defined as the combination of at least two reaction steps in a single reaction …
A cascade is defined as the combination of at least two reaction steps in a single reaction …
Hydrogen peroxide driven biocatalysis
In general, hydrogen peroxide is a stable and relatively mild oxidant and it can be regarded
as the ultimate “green” reagent because water and oxygen are the only by-products …
as the ultimate “green” reagent because water and oxygen are the only by-products …
Hydrocarbon synthesis via photoenzymatic decarboxylation of carboxylic acids
A recently discovered photodecarboxylase from Chlorella variabilis NC64A (Cv FAP) bears
the promise for the efficient and selective synthesis of hydrocarbons from carboxylic acids …
the promise for the efficient and selective synthesis of hydrocarbons from carboxylic acids …
Photobiocatalytic synthesis of chiral secondary fatty alcohols from renewable unsaturated fatty acids
En route to a bio-based chemical industry, the conversion of fatty acids into building blocks
is of particular interest. Enzymatic routes, occurring under mild conditions and excelling by …
is of particular interest. Enzymatic routes, occurring under mild conditions and excelling by …
Mechanistic studies of fatty acid activation by CYP152 peroxygenases reveal unexpected desaturase activity
M Pickl, S Kurakin, FG Cantú Reinhard, P Schmid… - ACS …, 2018 - ACS Publications
The majority of cytochrome P450 enzymes (CYPs) predominantly operate as
monooxygenases, but recently a class of P450 enzymes was discovered, that can act as …
monooxygenases, but recently a class of P450 enzymes was discovered, that can act as …
Chemo-enzymatic cascades to produce cycloalkenes from bio-based resources
Engineered enzyme cascades offer powerful tools to convert renewable resources into
value-added products. Man-made catalysts give access to new-to-nature reactivities that …
value-added products. Man-made catalysts give access to new-to-nature reactivities that …
Regioselective biocatalytic hydroxylation of fatty acids by cytochrome P450s
L Hammerer, CK Winkler, W Kroutil - Catalysis Letters, 2018 - Springer
Cytochrome P450 enzymes catalyze a broad set of C–H activation reactions, the most
prominent being hydroxylation. This review provides an overview of the regioselectivity (CH …
prominent being hydroxylation. This review provides an overview of the regioselectivity (CH …
The enigmatic P450 decarboxylase OleT is capable of, but evolved to frustrate, oxygen rebound chemistry
OleT is a cytochrome P450 enzyme that catalyzes the removal of carbon dioxide from
variable chain length fatty acids to form 1-alkenes. In this work, we examine the binding and …
variable chain length fatty acids to form 1-alkenes. In this work, we examine the binding and …
[HTML][HTML] Biosynthesis of organic molecules via artificial cascade reactions based on cytochrome P450 monooxygenases
RJ Li, Z Zhang, CG Acevedo-Rocha, J Zhao… - Green Synthesis and …, 2020 - Elsevier
Cytochrome P450 monooxygenases (P450s) play crucial roles in the oxyfunctionalization of
non-activated hydrocarbons, thus bridging the gap between simple molecules and high …
non-activated hydrocarbons, thus bridging the gap between simple molecules and high …
An engineered self-sufficient biocatalyst enables scalable production of linear α-olefins from carboxylic acids
C Lu, F Shen, S Wang, Y Wang, J Liu, WJ Bai… - ACS …, 2018 - ACS Publications
Fusing the decarboxylase OleTJE and the reductase domain of P450BM3 creates a self-
sufficient protein, OleT-BM3R, which is able to efficiently catalyze oxidative decarboxylation …
sufficient protein, OleT-BM3R, which is able to efficiently catalyze oxidative decarboxylation …