Sex differences may play a critical role in modulating how chronic or heavy alcohol use
impacts the brain to cause the development of alcohol use disorder (AUD). AUD is a …

Alcohol use disorder remains a substantial social, health, and economic problem and
problem drinking levels in women have been increasing in recent years. Understanding …

Background More women are being diagnosed with alcohol use disorder (AUD), are
increasing the amount of alcohol they are drinking, and are partaking in risky drinking …

Compulsive alcohol drinking is a key symptom of alcohol use disorder (AUD) that is
particularly resistant to treatment. An understanding of the biological factors that underly …

The neuropeptide hypocretin/orexin plays a broad and important role in physiological
functions ranging from addiction, stress, and anxiety to sleep, energy metabolism, and …

Abstract Alcohol Use Disorder (AUD) is a leading cause of death and disability worldwide,
but current treatments are insufficient in fully addressing the symptoms that often lead to …

Background One of the DSM‐5 criteria for Alcohol Use Disorder is continued alcohol
consumption despite negative consequences. This has been modeled in mice using …

Animal models of addictive behaviors are useful for uncovering neural mechanisms involved
in the development of dependence and for identifying risk factors for drug abuse. One such …

Rationale Animal models of compulsive drug use that continues despite negative
consequences can be used to investigate the neural mechanisms of addiction. However …

Introduction While substantial research has focused on the contribution of sex hormones to
driving elevated levels of alcohol drinking in female rodents, fewer studies have investigated …