As it was established that aging is not associated with massive neuronal loss, as was
believed in the mid‐20th Century, scientific interest has addressed the influence of aging on …

With an increasingly ageing population that is expected to double by 2050 in the US, it is
paramount that we further understand the neurological changes that occur during ageing …

Epigenetic variability (DNA methylation/demethylation, histone modifications, microRNA
regulation) is common in physiological and pathological conditions. Epigenetic alterations …

Population aging is accelerating rapidly worldwide, from 461 million people older than 65
years in 2004 to an estimated 2 billion people by 2050, leading to critical implications for the …

Unhealthy lifestyle choices, poor diet, and aging can have negative influences on cognition,
gradually increasing the risk for mild cognitive impairment (MCI) and the continuum …

The implication of epigenetic mechanisms in Alzheimer's disease (AD) has been
demonstrated in several studies. UNC0642, a specific and potent inhibitor of …

Abstract Alzheimer's disease (AD), the most common form of dementia in the elderly, has no
cure. Thus, the identification of key molecular mediators of cognitive decline in AD remains a …

Despite the growing evidence suggesting that long noncoding RNAs (lncRNAs) are critical
regulators of several biological processes, their functions in the nervous system remain …

Cognitive frailty (CF) is the conjunction of cognitive impairment without dementia and
physical frailty. While predictors of each element are well-researched, mechanisms of their …

Frailty is an aging related condition, which has been defined as a state of enhanced
vulnerability to stressors, leading to a limited capacity to meet homeostatic demands …