Oestrogens and their receptors contribute broadly to physiology and diseases. In
premenopausal women, endogenous oestrogens protect against cardiovascular, metabolic …

Aldosterone is one of the most essential hormones synthesized by the adrenal gland
because it regulates water and electrolyte balance. G protein–coupled estrogen receptor …

The renin angiotensin aldosterone system is a key regulator of blood pressure. Aldosterone
is the final effector of this pathway, acting predominantly via mineralocorticoid receptors …

Aldosterone exerts some of its effects not by binding to mineralocorticoid receptors, but
rather by acting via G protein‐coupled estrogen receptors (GPER). To determine if …

Aldosterone plays a key role in controlling blood pressure (BP) values by maintaining salt,
water, and body fluid homeostasis. Excess aldosterone production is associated with arterial …

Vasoactive molecules, such as vascular endothelial growth factor (VEGF) and endothelins,
share cytokine-like activities and regulate endothelial cell (EC) growth, migration, and …

Objective: Estrogen is indispensable in health and disease and mainly functions through its
receptors. The protection of the cardiovascular system by estrogen and its receptors has …

Blood pressure is lower in premenopausal women than in age-matched men; after
menopause blood pressure values and the prevalence of hypertension show opposite …

The mechanisms underlying hypertension are multifaceted and incompletely understood.
New evidence suggests that G protein-coupled estrogen receptor 1 (GPER1) mediates …

In addition to the α, β, and γ subunits of ENaC, human salt-sensing taste receptor cells
(TRCs) also express the δ-subunit. At present, it is not clear if the expression and function of …