A 48-year-old man with poorly controlled HIV presented with severe human monkeypox
virus (hMPXV) infection, having completed 2 weeks of tecovirimat at another hospital. He …

Human monkeypox is a viral zoonotic disease that occurs mostly in the rain forests of central
and western Africa. However, the disease recently emerged in the United States in imported …

The last case of endemic smallpox occurred in Somalia in 1977, and eradication of the
disease was declared in 1980. With no natural reservoir, variola virus, which causes …

The acyclic nucleoside phosphonates HPMPC (cidofovir), PMEA (adefovir), and PMPA
(tenofovir) have proved to be effective in vitro (cell culture systems) and in vivo (animal …

Cynomolgus monkeys (Macaca fascicularis) were exposed by fine-particle aerosol to lethal
doses of monkeypox virus, Zaire strain. Death, attributable to fibrinonecrotic …

We assessed the activities of 24 different antiviral compounds against smallpox (two strains
of variola major and one of variola minor), monkeypox, vaccinia and cowpox viruses by a …

Forty years after the last endemic smallpox case, variola virus (VARV) is still considered a
major threat to humans due to its possible use as a bioterrorism agent. For many years, the …

This chapter deals with poxviruses belonging to the family Poxviridae and subfamily
Chordopoxvirinae. The G+ C contents of orthopoxviruses, yatapoxviruses, Molluscum …

Cidofovir [(S)-1-(3-hydroxy-2-phosphonylmethoxypropyl) cytosine, HPMPC] has since 1996
been licensed for clinical use in the treatment of cytomegalovirus (CMV) retinitis in AIDS …

The large size of poxvirus genomes has stymied attempts to identify determinants
recognized by CD8+ T cells and greatly impeded development of mouse smallpox …