Protein kinase C (PKC) and Protein kinase D (PKD) isoforms can sense diacylglycerol
(DAG) generated in the different cellular compartments in various physiological processes …

Insulin resistance precedes and predicts the onset of type 2 diabetes (T2D) in susceptible
humans, underscoring its important role in the complex pathogenesis of this disease. Insulin …

Objective Endurance exercise training reduces insulin resistance, adipose tissue
inflammation and non-alcoholic fatty liver disease (NAFLD), an effect often associated with …

Sarcolipin (SLN) is a novel regulator of sarcoplasmic reticulum Ca 2+ ATPase (SERCA) in
muscle. SLN binding to SERCA uncouples Ca 2+ transport from ATP hydrolysis. By this …

Exercise training is a powerful means to combat metabolic diseases. Mice are extensively
used to investigate the benefits of exercise, but mild cold stress induced by ambient housing …

Glucose and lipid metabolism disorders caused by insulin resistance (IR) can lead to
metabolic disorders such as diabetes, obesity, and the metabolic syndrome. Early and …

Obesity contributes to systemic inflammation, which is associated with the varied
pathogenesis of neurodegenerative diseases. Growing evidence has demonstrated that …

Obesity induces oxidative stress by causing hyperglycemia and insulin resistance, while
contributing to cognitive and memory decline by inducing insulin resistance in the brain and …

Background China has a shortage of health workers in rural areas, but little research exists
on policies that attract qualified medical and nursing students to rural locations. We …

Although aging is associated with progressive adiposity and a decline in liver function, the
underlying molecular mechanisms and metabolic interplay are incompletely understood …