Aim Clinical resistance is a complex phenomenon in major human cancers involving
multifactorial mechanisms, and hypoxia is one of the key components that affect the cellular …

The DNA-dependent protein kinase (DNA-PK) is a pivotal component of the DNA repair
machinery that governs the response to DNA damage, serving to maintain genome integrity …

Sub-regions of hypoxia exist within all tumors and the presence of intratumoral hypoxia has
an adverse impact on patient prognosis. Tumor hypoxia can increase metastatic capacity …

The toxic effects and potential mechanisms of aflatoxin B1 (AFB1), aflatoxin M1 (AFM1), and
AFB1+ AFM1 in the kidney were studied and compared in HEK 293 cells model and CD‐1 …

Hypoxia, as a pervasive feature in the microenvironment of solid tumors, plays a significant
role in cancer progression, metastasis, and ultimately clinical outcome. One key cellular …

DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a pleiotropic protein kinase
that plays critical roles in cellular processes fundamental to cancer. DNA-PKcs expression …

Hypoxia is a hallmark of the tumour microenvironment with profound effects on tumour
biology, influencing cancer progression, the development of metastasis and patient …

DNA damaging agents are most common in chemotherapeutic molecules that act against
cancer. However, cancer cells possess inherent biological features to overcome DNA …

Abnormal rates of growth together with metastatic potential and lack of susceptibility to
cellular signals leading to apoptosis are widely investigated characteristics of tumors that …

The toxicity and related mechanisms of aflatoxin B1 (AFB1) and aflatoxin M1 (AFM1) in the
mouse kidney were studied, and the role of l-proline in alleviating kidney damage was …