Neurotrophins and their receptors modulate multiple signalling pathways to regulate
neuronal survival and to maintain axonal and dendritic networks and synaptic plasticity …

The specialized architecture of neurons necessitates unique modes of intracellular
communication to allow for cell survival, the ability to detect and respond to injury and …

VPS10P-domain receptors, such as SORLA and sortilin, constitute a recently identified class
of type-1 receptors that are expressed in neurons. Family members are multifunctional …

The striking differences between the clinical symptoms of tetanus and botulism have been
ascribed to the different fate of the parental neurotoxins once internalised in motor neurons …

To reach the central nervous system (CNS), pathogens have to circumvent the wall of tightly
sealed endothelial cells that compose the blood–brain barrier. Neuronal projections that …

Axonal targeting of trophic receptors is critical for neuronal responses to extracellular
developmental cues, yet the underlying trafficking mechanisms remain unclear. Here, we …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease caused by the
degeneration of upper and lower motor neurons. Defects in axonal transport have been …

Neurons are highly polarized cells that rely on the intracellular transport of organelles. This
process is regulated by molecular motors such as dynein and kinesins and the Rab family of …

Rabies virus (RABV) is a neurotropic virus that depends on long distance axonal transport in
order to reach the central nervous system (CNS). The strategy RABV uses to hijack the …

Endocytosis and endosomal trafficking play a multitude of roles in cellular function beyond
regulating entry of essential nutrients. In this review, we discuss the cell biological principles …