Systemic immune activation is a striking consequence of HIV‐1 infection. Even in
virologically suppressed patients, some hyperactivity of the immune system and even of the …

Cancer, a proliferative disease hallmarked by abnormal cell growth and spread, is largely
dependent on tumor neoangiogenesis, with evidence of vascular endothelial dysfunction …

Thrombotic thrombocytopenic purpura (TTP) and haemolytic uraemic syndrome (HUS) are
today often regarded as variants of one syndrome denoted as TTP/HUS, characterized by …

DNA single strand breakage and activation of the nuclear enzyme poly (ADP-ribose)
synthetase (PARS) contribute to peroxynitrite-induced cellular injury. We investigated the …

Microparticles are circulating, phospholipid rich, submicron particles released from the
membranes of endothelial cells, platelets, leucocytes and erythrocytes. Investigation into …

Hemolytic uremic syndrome (HUS) is characterized by hemolytic anemia with fragmented
erythrocytes, thrombocytopenia, and acute renal failure. Lack of complement inactivating …

Transplantation-associated thrombotic microangiopathy (TA-TMA) is an infrequent but
devastating syndrome that occurs in allogeneic hematopoietic stem cell transplant …

This overview summarizes the history of thrombotic thrombocytopenic purpura (TTP) from its
initial recognition in 1924 as a most often fatal disease to the discovery in 1997 of ADAMTS …

Objectives To evaluate the presence of premature atherosclerotic lesions of epiaortic
vessels in HIV-1-infected protease inhibitor-(PI) treated patients compared with PI-naive …

Endothelial injury is believed to be a key initiating event in the pathogenesis of thrombotic
thrombocytopenic purpura (TTP), leading to platelet activation and formation of platelet‐rich …