[HTML][HTML] Tumors produce glucocorticoids by metabolite recycling, not synthesis, and activate Tregs to promote growth
MD Taves, S Otsuka, MA Taylor… - The Journal of …, 2023 - Am Soc Clin Investig
Glucocorticoids are steroid hormones with potent immunosuppressive properties. Their
primary source is the adrenals, where they are generated via de novo synthesis from …
primary source is the adrenals, where they are generated via de novo synthesis from …
An aggressive interaction rapidly increases brain androgens in a male songbird during the non-breeding season
Aggression is a crucial behavior that impacts access to limited resources in different
environmental contexts. Androgens synthesized by the gonads promote aggression during …
environmental contexts. Androgens synthesized by the gonads promote aggression during …
Isoflurane stress induces region-specific glucocorticoid levels in neonatal mouse brain
JE Hamden, KM Gray, M Salehzadeh… - Journal of …, 2022 - joe.bioscientifica.com
The profound programming effects of early life stress (ELS) on brain and behavior are
thought to be primarily mediated by adrenal glucocorticoids (GCs). However, in mice …
thought to be primarily mediated by adrenal glucocorticoids (GCs). However, in mice …
[HTML][HTML] Profiling of adrenal corticosteroids in blood and local tissues of mice during chronic stress
K Vagnerová, M Jágr, C Mekadim, P Ergang… - Scientific Reports, 2023 - nature.com
Stress increases plasma concentrations of corticosteroids, however, their tissue levels are
unclear. Using a repeated social defeat paradigm, we examined the impact of chronic stress …
unclear. Using a repeated social defeat paradigm, we examined the impact of chronic stress …
Environmental enrichment protects against sepsis-associated encephalopathy-induced learning and memory deficits by enhancing the synthesis and release of …
S Jiang, YQ Wang, Y Tang, X Lu… - Journal of Inflammation …, 2022 - Taylor & Francis
Background As a severe complication of sepsis, sepsis-associated encephalopathy (SAE)
usually manifests as impaired learning and memory ability in survivors. Previous studies …
usually manifests as impaired learning and memory ability in survivors. Previous studies …
Extra-adrenal glucocorticoid and mineralocorticoid biosynthesis
CE Gomez-Sanchez, EP Gomez-Sanchez - Endocrinology, 2022 - academic.oup.com
The glucocorticoids (GCs) corticosterone and cortisol and the mineralocorticoid aldosterone
are synthesized and secreted from the adrenal gland into the circulation and then …
are synthesized and secreted from the adrenal gland into the circulation and then …
Effects of neonatal lipopolysaccharide exposure on steroid regulation in the adult mouse brain and blood
H Bajaj - 2024 - open.library.ubc.ca
Early-life infections can have enduring consequences on brain development and function.
Bacterial infections during development increase the risk for neuropsychiatric disorders later …
Bacterial infections during development increase the risk for neuropsychiatric disorders later …
Inheriting the toxic effects of our ancestors diet: prenatal glyphosate exposure induces colonic inflammation, immune metabolic dysfunction and behavioral deficits in …
JA Barnett - 2024 - open.library.ubc.ca
Glyphosate, commonly known as Roundup®, is heavily used in Canada, with over 50 million
kilograms purchased annually. Its pre-harvest use results in residues in Canadian food …
kilograms purchased annually. Its pre-harvest use results in residues in Canadian food …
Effects of lipopolysaccharide on local glucocorticoid regulation in the mouse nervous and immune systems
M Salehzadeh Moghadami - 2024 - open.library.ubc.ca
Immune activation during early development has long-term effects on health, increasing the
risk for neuropsychiatric disorders (eg, mood disorders, schizophrenia, autism) and immune …
risk for neuropsychiatric disorders (eg, mood disorders, schizophrenia, autism) and immune …
The vital role of growth hormone in control of the COVID-19 pandemic era
K Gautam, P Gautam - The Journal of Rural Advancement, 2023 - jra.idtra.co.in
The COVID-19 pandemic is a worldwide pandemic challenge that started in China and
spread to almost all countries. The causative virus was identified as highly contagious and …
spread to almost all countries. The causative virus was identified as highly contagious and …