Glaucoma is an important cause of irreversible blindness, characterized by optic nerve
anomalies. Increased intraocular pressure (IOP) and aging are major risk factors. Retinal …

Secreted protein acidic and rich in cysteine (SPARC), also termed osteonectin or BM-40, is a
matricellular protein which regulates cell adhesion, extracellular matrix production, growth …

Glaucoma has no cure and is a sight-threatening neurodegenerative disease affecting more
than 100 million people worldwide, with primary open angle glaucoma (POAG) being the …

Chronically elevated intraocular pressure (IOP) is the major risk factor of primary open-angle
glaucoma, a leading cause of blindness. Dysfunction of the trabecular meshwork (TM) …

We aimed to identify and compare microRNAs (miRNAs) from individual aqueous humor
samples between normal-tension glaucoma (NTG) patients and normal controls. Aqueous …

Metabolic dysfunction plays a crucial role in the pathogenesis of glaucoma. In this study, we
used Olink proteomics profiling to identify potential biomarkers for glaucoma. Aqueous …

Glaucoma is a disease with characteristic optic neuropathy and loss of vision, leading to
blindness, and primary open-angle glaucoma (POAG) is the most common glaucoma type …

Glaucoma is a leading cause of blindness worldwide with complex pathogenesis. The
excessive proliferation and fibrosis of human tenon capsule fibroblasts (HTFs) trigger the …

Background Lowe syndrome (LS) is caused by loss-of-function mutations in the X-linked
gene OCRL, which codes for an inositol polyphosphate 5-phosphatase that plays a key role …

Glaucoma is a neurodegenerative disorder characterized by the loss of retinal ganglion cells
and optic nerve fibers, resulting in the loss of visual field. Primary open-angle glaucoma …