Investigating the origins of the mutational signatures in cancer

G Boysen, LB Alexandrov, R Rahbari… - Nucleic Acids …, 2025 - academic.oup.com
Most of the risk factors associated with chronic and complex diseases, such as cancer, stem
from exogenous and endogenous exposures experienced throughout an individual's life …

Multi-adductomics: Advancing mass spectrometry techniques for comprehensive exposome characterization

MR Chao, YJ Chang, MS Cooke, CW Hu - TrAC Trends in Analytical …, 2024 - Elsevier
Adductomics, an emerging field within the'omics sciences, focuses on the formation and
prevalence of DNA, RNA, and protein adducts induced by endogenous and exogenous …

Molecular Mechanism of RNA Polymerase II Transcriptional Mutagenesis by the Epimerizable DNA Lesion, Fapy· dG

S Gao, P Hou, J Oh, D Wang… - Journal of the American …, 2024 - ACS Publications
Oxidative DNA lesions cause significant detrimental effects on a living species. Two major
DNA lesions resulting from dG oxidation, 8-oxo-7, 8-dihydro-2′-deoxyguanosine (8 …

An Integrated LC-MS/MS Platform for Noninvasive Urinary Nucleus Acid Adductomics: A Pilot Study for Tobacco Exposure

X Li, H Zeng, L Zhang, J Zhang, Y Guo… - Journal of Hazardous …, 2024 - Elsevier
Tobacco smoke exposure significantly increases the level of global nucleoside damage. To
evaluate all aspects of nucleic acid (NA) modifications, NA adductomics analyzes DNA, RNA …

Pivotal Role of Mass Spectrometry for the Assessment of Exposure to Reactive Chemical Contaminants: From the Exposome to the Adductome

L Debrauwer, L Mervant, O Laprevote… - Mass Spectrometry …, 2024 - Wiley Online Library
ABSTRACT A large part of the Human chemical exposome is now well characterized, and its
health effects has been widely documented, although precise causal links remain difficult to …

[HTML][HTML] DNA Adductomics: A Narrative Review of Its Development, Applications, and Future

M Cao, X Zhang - Biomolecules, 2024 - mdpi.com
DNA adductomics is the global study of all DNA adducts and was first proposed in 2006 by
the Matsuda group. Its development has been greatly credited to the advances in mass …

Adjuvant Activity and Toxicological Risks of Lipid Nanoparticles Contained in the COVID‑19 “mRNA Vaccines”

G Segalla - International Journal of Vaccine Theory, Practice, and …, 2023 - mail.ijvtpr.com
The LNPs reportedly used as the platform by Pfizer/BioNTech for its SARS-CoV-2 “mRNA
vaccines” allegedly consist of a mixture of phospholipids, cholesterol, PEGylated lipids, and …

Expanding Computational Resources for the Discovery of Molecular Biomarkers of Exposure

KJ Murray - 2024 - search.proquest.com
Recurrent exposure to genotoxic chemicals and other harmful environmental agents is
directly related to the development of adverse phenotypes, carcinogenesis, and …

[PDF][PDF] Attività Adiuvante e Rischi Tossicologici delle Nanoparticelle Lipidiche Contenute nei" Vaccini a mRNA" COVID19

G Segalla - avvocatiliberi.legal
Secondo quanto riferito, le nanoparticelle lipidiche (LNP), utilizzate come piattaforma da
Pfizer/BioNTech per i suoi" vaccini a mRNA" SARS-CoV-2, sarebbero costituiti da una …