Sarcomas are heterogeneous bone and soft tissue cancers representing the second most
common tumor type in children and adolescents. Histology and genetic profiling discovered …

Conditional protein degradation tags (degrons) are usually> 100 amino acids long or are
triggered by small molecules with substantial off-target effects, thwarting their use as specific …

Degron tagging allows proteins of interest to be rapidly degraded, in a reversible and
tuneable manner, in response to a chemical stimulus. This provides numerous opportunities …

To address the limitation associated with degron based systems, we have developed iTAG,
a synthetic tag based on IMiDs/CELMoDs mechanism of action that improves and addresses …

The degradation tag (dTAG) system for target protein degradation can remove proteins from
biological systems without the drawbacks of some genetic methods, such as slow kinetics …

Molecular tools for optogenetic control allow for spatial and temporal regulation of cell
behavior. In particular, light-controlled protein degradation is a valuable mechanism of …

Protein-targeted degradation is an emerging and promising therapeutic approach. The
specificity of degradation and the maintenance of cellular homeostasis are determined by …

Immunomodulatory imide drugs (IMiDs) including thalidomide, lenalidomide, and
pomalidomide, can be used to induce degradation of a protein of interest that is fused to a …

Self-labeling protein tags are an efficient means to visualize, manipulate, and isolate
engineered fusion proteins with suitable chemical probes. The SNAP-tag, which covalently …

Auxin-inducible degron (AID) technology is powerful for chemogenetic control of proteolysis.
However, generation of human cell lines to deplete endogenous proteins with AID remains …