Robustness: linking strain design to viable bioprocesses

L Olsson, P Rugbjerg, LT Pianale, C Trivellin - Trends in Biotechnology, 2022 - cell.com
Microbial cell factories are becoming increasingly popular for the sustainable production of
various chemicals. Metabolic engineering has led to the design of advanced cell factories; …

The antioxidant, anti-apoptotic, and proliferative potency of argan oil against betamethasone-induced oxidative renal damage in rats

SH Orabi, TS Allam, SM Shawky, EAE Tahoun… - Biology, 2020 - mdpi.com
Simple Summary The present study aimed to investigate the protective effect of argan oil
against nephrotoxic effect following overdose and long-term administration of …

Application of conditional robust calibration to ordinary differential equations models in computational systems biology: A comparison of two sampling strategies

F Bianconi, C Antonini, L Tomassoni… - IET Systems …, 2020 - Wiley Online Library
Mathematical modelling is a widely used technique for describing the temporal behaviour of
biological systems. One of the most challenging topics in computational systems biology is …

[图书][B] Theoretical physics for biological systems

P Lecca, A Re - 2019 - books.google.com
Quantum physics provides the concepts and their mathematical formalization that lend
themselves to describe important properties of biological networks topology, such as …

Robust Calibration of High Dimension Nonlinear Dynamical Models for Omics Data: An Application in Cancer Systems Biology

F Bianconi, C Antonini, L Tomassoni… - IEEE Transactions on …, 2018 - ieeexplore.ieee.org
In computational mathematical modeling of biological systems, most model parameters,
such as initial conditions, kinetics, and scale factors, are usually unknown because they …

Robustness analysis for quantitative assessment of vaccination effects and SARS-CoV-2 lineages in Italy

C Antonini, S Calandrini, F Bianconi - BMC Infectious Diseases, 2022 - Springer
Abstract Background In Italy, the beginning of 2021 was characterized by the emergence of
new variants of SARS-CoV-2 and by the availability of effective vaccines that contributed to …

Mathematical modeling and robustness analysis to unravel COVID-19 transmission dynamics: the Italy case

C Antonini, S Calandrini, F Stracci, C Dario, F Bianconi - Biology, 2020 - mdpi.com
Simple Summary In the absence of vaccines and antiviral therapies against COVID-19, non-
pharmaceutical interventions represent the only weapon to fight this new coronavirus. In this …

CRA toolbox: software package for conditional robustness analysis of cancer systems biology models in MATLAB

F Bianconi, C Antonini, L Tomassoni, P Valigi - BMC bioinformatics, 2019 - Springer
Background In cancer research, robustness of a complex biochemical network is one of the
most relevant properties to investigate for the development of novel targeted therapies. In …

A new Bayesian methodology for nonlinear model calibration in Computational Systems Biology

F Bianconi, L Tomassoni, C Antonini… - Frontiers in Applied …, 2020 - frontiersin.org
Computational modeling is a common tool to quantitatively describe biological processes.
However, most model parameters are usually unknown because they cannot be directly …

[HTML][HTML] Reverse phase protein array (RPPA) combined with computational analysis to unravel relevant prognostic factors in non-small cell lung cancer (NSCLC): a …

V Ludovini, R Chiari, L Tomassoni, C Antonini… - Oncotarget, 2017 - ncbi.nlm.nih.gov
In this work high throughput technology and computational analysis were used to study two
stage IV lung adenocarcinoma patients treated with standard chemotherapy with markedly …