Inflammatory bowel disease (IBD), which includes Crohn's disease and ulcerative colitis, is a
chronic, relapsing immune-mediated disease with a varying and sometimes severe disease …

Major depressive disorder (MDD) is a psychiatric disease of still poorly understood
molecular etiology. Extensive studies at different molecular levels point to a high complexity …

Serotonin reuptake inhibitor antidepressants, including selective serotonin reuptake
inhibitors (SSRIs; ie, citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine, and …

Irritable bowel syndrome (IBS) results from disordered brain–gut interactions. Identifying
susceptibility genes could highlight the underlying pathophysiological mechanisms. We …

The genetic dissection of major depressive disorder (MDD) ranks as one of the success
stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying …

Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of
neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic …

Major depression is a debilitating psychiatric illness that is typically associated with low
mood and anhedonia. Depression has a heritable component that has remained difficult to …

We present the largest exome sequencing study of autism spectrum disorder (ASD) to date
(n= 35,584 total samples, 11,986 with ASD). Using an enhanced analytical framework to …

Genetic correlations estimated from genome-wide association studies (GWASs) reveal
pervasive pleiotropy across a wide variety of phenotypes. We introduce genomic structural …

Neuroticism is an important risk factor for psychiatric traits, including depression, anxiety,,
and schizophrenia,–. At the time of analysis, previous genome-wide association studies …