We describe the RNA folding problem and contrast it with the much more difficult protein
folding problem. RNA has four similar monomer units, whereas proteins have 20 very …

The genetic code is degenerate, in that 20 amino acids are encoded by 61 triplet codes. In
1966, Francis Crick hypothesized that the cell's limited number of tRNAs decoded the …

Predicting RNA three-dimensional structures from sequence could accelerate
understanding of the growing number of RNA molecules being discovered across biology …

Thermodynamics of 39 oligonucleotides with internal G⊙ T mismatches dissolved in 1 M
NaCl were determined from UV absorbance versus temperature profiles. These data were …

Specific tertiary structural motifs determine the complete architecture of RNA molecules (see
picture for examples). Within the last few years a number of high‐resolution crystal structures …

RNA tertiary structure prediction has been based almost entirely on base-pairing constraints
derived from phylogenetic covariation analysis. We describe here a complementary …

Hairpins represent the dominant secondary structure element in RNA. Certain sequences
are found with exceptional frequency in many RNAs and are characterized by exceptionally …

Nucleic acid molecules play a central role in cell biological processes. DNA's main role is to
act as the carrier of genetic information. Furthermore, DNA is transcribed into RNA by a …

Thermodynamics of 23 oligonucleotides with internal single C· T mismatches were obtained
by measuring UV absorbance as a function of temperature. Results from these 23 duplexes …

The many important biological functions of RNA range from propagation of genetic
information to catalysis in RNA processing and protein synthesis [l]. This diverse array of …