Promoter DNA hypermethylation and paradoxical gene activation
DNA methylation is a stable epigenetic modification that contributes to the spatiotemporal
regulation of gene expression. The manner in which DNA methylation contributes to …
regulation of gene expression. The manner in which DNA methylation contributes to …
[HTML][HTML] Integrative multi-omics and systems bioinformatics in translational neuroscience: A data mining perspective
Bioinformatic analysis of large and complex omics datasets has become increasingly useful
in modern day biology by providing a great depth of information, with its application to …
in modern day biology by providing a great depth of information, with its application to …
ChIP-Atlas 2021 update: a data-mining suite for exploring epigenomic landscapes by fully integrating ChIP-seq, ATAC-seq and Bisulfite-seq data
Abstract ChIP-Atlas (https://chip-atlas. org) is a web service providing both GUI-and API-
based data-mining tools to reveal the architecture of the transcription regulatory landscape …
based data-mining tools to reveal the architecture of the transcription regulatory landscape …
[HTML][HTML] The International Human Epigenome Consortium: a blueprint for scientific collaboration and discovery
HG Stunnenberg, S Abrignani, D Adams, M de Almeida… - Cell, 2016 - cell.com
The International Human Epigenome Consortium (IHEC) coordinates the generation of a
catalog of high-resolution reference epigenomes of major primary human cell types. The …
catalog of high-resolution reference epigenomes of major primary human cell types. The …
Ch IP‐Atlas: a data‐mining suite powered by full integration of public Ch IP‐seq data
We have fully integrated public chromatin chromatin immunoprecipitation sequencing (Ch IP‐
seq) and DN ase‐seq data (n> 70,000) derived from six representative model organisms …
seq) and DN ase‐seq data (n> 70,000) derived from six representative model organisms …
The BLUEPRINT data analysis portal
The impact of large and complex epigenomic datasets on biological insights or clinical
applications is limited by the lack of accessibility by easy, intuitive, and fast tools. Here, we …
applications is limited by the lack of accessibility by easy, intuitive, and fast tools. Here, we …
Making sense of the epigenome using data integration approaches
Epigenetic research involves examining the mitotically heritable processes that regulate
gene expression, independent of changes in the DNA sequence. Recent technical …
gene expression, independent of changes in the DNA sequence. Recent technical …
An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping
Z Wang, Q Liang, X Qian, B Hu, Z Zheng… - Nature …, 2023 - nature.com
Genetic sharing is extensively observed for autoimmune diseases, but the causal variants
and their underlying molecular mechanisms remain largely unknown. Through systematic …
and their underlying molecular mechanisms remain largely unknown. Through systematic …
A cell-free DNA metagenomic sequencing assay that integrates the host injury response to infection
High-throughput metagenomic sequencing offers an unbiased approach to identify
pathogens in clinical samples. Conventional metagenomic sequencing, however, does not …
pathogens in clinical samples. Conventional metagenomic sequencing, however, does not …
Panomics for precision medicine
C Sandhu, A Qureshi, A Emili - Trends in molecular medicine, 2018 - cell.com
Medicine is poised to undergo a digital transformation. High-throughput platforms are
creating terabytes of genomic, transcriptomic, proteomic, and metabolomic data. The …
creating terabytes of genomic, transcriptomic, proteomic, and metabolomic data. The …