Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Brain-derived neurotrophic factor (BDNF)—a member of a small family of secreted proteins
that includes nerve growth factor, neurotrophin 3 and neurotrophin 4—has emerged as a …

The maturation of human pluripotent stem cell (hPSC)-derived neurons mimics the
protracted timing of human brain development, extending over months to years for reaching …

Fast synaptic communication in the brain requires synchronous vesicle fusion that is evoked
by action potential-induced Ca2+ influx. However, synaptic terminals also release …

▪ Abstract Neurotrophins regulate development, maintenance, and function of vertebrate
nervous systems. Neurotrophins activate two different classes of receptors, the Trk family of …

Neurotrophic factors, particularly brain-derived neurotrophic factor (BDNF) and other
members of the neurotrophin family, are central mediators of the activity-dependent plasticity …

CREB is a transcription factor implicated in the control of adaptive neuronal responses.
Although one function of CREB in neurons is believed to be the regulation of genes whose …

The role of neurotrophins as regulatory factors that mediate the differentiation and survival of
neurons has been well described. More recent evidence indicates that neurotrophins may …

Chronic exposure to uncontrollable stress causes loss of spines and dendrites in the
prefrontal cortex (PFC), a recently evolved brain region that provides top-down regulation of …

▪ Abstract Despite considerable evidence that neuronal activity influences the organization
and function of circuits in the developing and adult brain, the molecular signals that translate …