The fidelity of DNA synthesis by eukaryotic replicative and translesion synthesis polymerases
SD McCulloch, TA Kunkel - Cell research, 2008 - nature.com
In their seminal publication describing the structure of the DNA double helix 1, Watson and
Crick wrote what may be one of the greatest understatements in the scientific literature …
Crick wrote what may be one of the greatest understatements in the scientific literature …
Fidelity of DNA replication—a matter of proofreading
A Bębenek, I Ziuzia-Graczyk - Current genetics, 2018 - Springer
DNA that is transmitted to daughter cells must be accurately duplicated to maintain genetic
integrity and to promote genetic continuity. A major function of replicative DNA polymerases …
integrity and to promote genetic continuity. A major function of replicative DNA polymerases …
Coronaviruses lacking exoribonuclease activity are susceptible to lethal mutagenesis: evidence for proofreading and potential therapeutics
No therapeutics or vaccines currently exist for human coronaviruses (HCoVs). The Severe
Acute Respiratory Syndrome-associated coronavirus (SARS-CoV) epidemic in 2002–2003 …
Acute Respiratory Syndrome-associated coronavirus (SARS-CoV) epidemic in 2002–2003 …
Exonuclease mutations in DNA polymerase epsilon reveal replication strand specific mutation patterns and human origins of replication
E Shinbrot, EE Henninger, N Weinhold… - Genome …, 2014 - genome.cshlp.org
Tumors with somatic mutations in the proofreading exonuclease domain of DNA polymerase
epsilon (POLE-exo*) exhibit a novel mutator phenotype, with markedly elevated TCT→ TAT …
epsilon (POLE-exo*) exhibit a novel mutator phenotype, with markedly elevated TCT→ TAT …
[HTML][HTML] Processing ribonucleotides incorporated during eukaryotic DNA replication
JS Williams, SA Lujan, TA Kunkel - Nature reviews Molecular cell …, 2016 - nature.com
The information encoded in DNA is influenced by the presence of non-canonical
nucleotides, the most frequent of which are ribonucleotides. In this Review, we discuss …
nucleotides, the most frequent of which are ribonucleotides. In this Review, we discuss …
DNA replication—a matter of fidelity
RA Ganai, E Johansson - Molecular cell, 2016 - cell.com
The fidelity of DNA replication is determined by many factors, here simplified as the
contribution of the DNA polymerase (nucleotide selectivity and proofreading), mismatch …
contribution of the DNA polymerase (nucleotide selectivity and proofreading), mismatch …
[HTML][HTML] DNA polymerases and human disease
LA Loeb, RJ Monnat Jr - Nature Reviews Genetics, 2008 - nature.com
The human genome encodes at least 14 DNA-dependent DNA polymerases—a surprisingly
large number. These include the more abundant, high-fidelity enzymes that replicate the …
large number. These include the more abundant, high-fidelity enzymes that replicate the …
DNA polymerases divide the labor of genome replication
SA Lujan, JS Williams, TA Kunkel - Trends in cell biology, 2016 - cell.com
DNA polymerases synthesize DNA in only one direction, but large genomes require RNA
priming and bidirectional replication from internal origins. We review here the physical …
priming and bidirectional replication from internal origins. We review here the physical …
Evolving views of DNA replication (in) fidelity
TA Kunkel - Cold Spring Harbor symposia on quantitative …, 2009 - symposium.cshlp.org
Symposium 74_Evolution: The Molecular Landscape Page 1 In organisms from viruses to
man, the fidelity with which genetic information is replicated depends on the ability of …
man, the fidelity with which genetic information is replicated depends on the ability of …
Dividing the workload at a eukaryotic replication fork
TA Kunkel, PM Burgers - Trends in cell biology, 2008 - cell.com
Efficient and accurate replication of the eukaryotic nuclear genome requires DNA
polymerases (Pols) α, δ and ɛ. In all current replication fork models, polymerase α initiates …
polymerases (Pols) α, δ and ɛ. In all current replication fork models, polymerase α initiates …